Results 71 to 80 of about 1,844,796 (395)

Modeling somatic computation with non-neural bioelectric networks [PDF]

Sci Rep 9, 18612 (2019), 2019
The field of basal cognition seeks to understand how adaptive, context-specific behavior occurs in non-neural biological systems. Embryogenesis and regeneration require plasticity in many tissue types to achieve structural and functional goals in diverse circumstances.
arxiv   +1 more source

In vivo biocompatibility of boron nitride nanotubes: effects on stem cell biology and tissue regeneration in planarians.

Nanomedicine, 2015
AIM Boron nitride nanotubes (BNNTs) represent an extremely interesting class of nanomaterials, and recent findings have suggested a number of applications in the biomedical field. Anyhow, extensive biocompatibility investigations are mandatory before any
A. Salvetti, L. Rossi, Paola Iacopetti, Xia Li, Simone Nitti, T. Pellegrino, V. Mattoli, D. Golberg, G. Ciofani   +8 more
semanticscholar   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

Epigenetic reprogramming of muscle progenitors: inspiration for clinical therapies [PDF]

, 2015
In the context of regenerative medicine, based on the potential of stem cells to restore diseased tissues, epigenetics is becoming a pivotal area of interest.
Consalvi, Silvia, Saccone, Valentina, Sandona', Martina   +2 more
core   +10 more sources

Graft survival of major histocompatibility complex deficient stem cell-derived retinal cells

Communications Medicine
Background Gene editing of immunomodulating molecules is a potential transplantation strategy to control immune rejection. As we noticed the successful transplantation of retinal pigment epithelium (RPE) derived from embryonic stem cells of a cynomolgus ...
Masaaki Ishida, Tomohiro Masuda, Noriko Sakai, Yoko Nakai-Futatsugi, Hiroyuki Kamao, Takashi Shiina, Masayo Takahashi, Sunao Sugita   +7 more
doaj   +1 more source

Biphasic Role of Tgf-β Signaling during Müller Glia Reprogramming and Retinal Regeneration in Zebrafish

iScience, 2020
Summary: Tgf-β signaling is a major antiproliferative pathway governing different biological functions, including cellular reprogramming. Upon injury, Müller glial cells of zebrafish retina reprogram to form progenitors (MGPCs) essential for regeneration.
Poonam Sharma, Shivangi Gupta, Mansi Chaudhary, Soumitra Mitra, Bindia Chawla, Mohammad Anwar Khursheed, Navnoor Kaur Saran, Rajesh Ramachandran   +7 more
doaj  

Limb regeneration revisited [PDF]

, 2009
The investigation of vertebrate limb regeneration, a favorite topic of early developmental biologists, is enjoying a renaissance thanks to recently developed molecular and genetic tools, as indicated in recent papers in BMC Biology and BMC Developmental ...
Tabin, Clifford J, Whited, Jessica L
core   +2 more sources

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

Chemically-induced photoreceptor degeneration and protection in mouse iPSC-derived three-dimensional retinal organoids

Stem Cell Research, 2017
Induced pluripotent stem cells (iPSCs), which can be differentiated into various tissues and cell types, have been used for clinical research and disease modeling.
Shin-ichiro Ito, Akishi Onishi, Masayo Takahashi   +2 more
doaj   +1 more source

Unbiased on-lattice domain growth [PDF]

Phys. Rev. E 100, 063307 (2019), 2019
Domain growth is a key process in many areas of biology, including embryonic development, the growth of tissue, and limb regeneration. As a result, mechanisms for incorporating it into traditional models for cell movement, interaction, and proliferation are of great importance. A previously well-used method in order to incorporate domain growth into on-
arxiv   +1 more source