Results 31 to 40 of about 1,644 (225)

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Integrated regenerative braking control strategy for the accelerator pedal of mine trackless electric vehicle for auxiliary transportation

Meitan xuebao
During the long-distance downhill operation of coal mine trackless auxiliary transportation vehicles in inclined shaft, a considerable amount of braking energy is available for recovery.
Zhongbin WU, Zhiyong REN, Yuan ZHAO, Jun ZHANG   +3 more
doaj   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

Advanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao, Bin Gu, Hui Zhao, Kun Tan, Qin Zhao, Zhengjun Shang   +5 more
wiley   +1 more source

Leading the Pack: Next‐Generation Batteries for Humanoid Robotics

Advanced Science, EarlyView.
Humanoid robots challenge traditional and anticipated energy technologies. Humanoid robot benchmarks of runtimes and energy demands for industry applications inform humanoid robot battery design choices at the cell level, pack level, and system level.
Matthew Bergschneider, Jiaqi Ke, Jin Luo, Laisuo Su, Thomas Campbell, Yue Zhou, Kyeongjae Cho   +6 more
wiley   +1 more source

Study on Differential Regenerative Braking Torque Control to Increase the Stability of the Small Electric Vehicle with Four In-Wheel Motors

MATEC Web of Conferences, 2017
Based on the advantages of the electric motor such as fast and precise torque response, the performance of the electric vehicle (EV) can be improved. During braking or driving on the cornering, the vehicle will over steer or under steer if a car turns by
Ali N. M., Peeie M. H., Rasid M. A. H., Ogino H.   +3 more
doaj   +1 more source

A Control Algorithm for the Novel Regenerative–Mechanical Coupled Brake System with by-Wire Based on Multidisciplinary Design Optimization for an Electric Vehicle

Energies, 2018
Current regenerative braking systems in electric vehicles have several problems, such as complex structures, too many control parameters, and inconsistent braking responses.
Changran He, Guoye Wang, Zhangpeng Gong, Zhichao Xing, Dongxin Xu   +4 more
doaj   +1 more source

Hypothalamic Control of Liver Health and Disease: From Circuits to Pathophysiology and Therapies

Advanced Science, EarlyView.
This review delineates the hypothalamic circuits that control liver homeostasis via autonomic and neuroendocrine pathways. Dysregulation of this hypothalamus–liver axis drives disease progression across a spectrum including steatotic liver disease, liver inflammation and injury, fibrosis, cirrhosis, and hepatocellular carcinoma.
Qin Tang, Jiahui Li, Haiying Song, Ailin Zhang, Haifeng Zeng, Yining Xu, Li Mo, Jinhan He   +7 more
wiley   +1 more source

Research on Hierarchical Sliding Mode–Fuzzy Combined Regenerative Braking Control Strategy Optimized by Adaptive Network-Based Fuzzy Inference System (ANFIS)

Actuators
The capability of recovering a portion of braking energy during vehicle deceleration is one of the distinctive advantages of new energy vehicles (EVs) over Conventional Internal Combustion Engine Vehicles (ICEVs).
Bing Fu, Yuzi Tan, Weihao Ai, Jingang Liu, Liang Yu   +4 more
doaj   +1 more source

Regenerative Braking Optimization of Lightweight Vehicle based on Vehicle Model

Chemical Engineering Transactions, 2022
The usage of regenerative braking highly improves the overall energy efficiency of electric vehicles. In this paper, the model-based optimization of the torque profile is determined in the regenerative braking process of a lightweight electric vehicle ...
Zoltán Pusztai, Péter Korös, Ferenc Szauter, Ferenc Friedler   +3 more
doaj   +1 more source

Endothelial miR‐15a/16‐1 Regulation of SYNE1 Mediates Structural and Functional Recovery after Traumatic Brain Injury

Advanced Science, EarlyView.
Endothelial miR‐15a/16‐1 deletion promotes long‐term recovery after traumatic brain injury by restoring SYNE1 expression. Enhanced endothelial SYNE1 preserves vascular integrity, protects white and gray matter, and improves neurological function. The endothelial miR‐15a/16‐1–SYNE1 axis emerges as a key regulator of neurovascular repair and a potential ...
Shun Li, Na Qiu, Chao Zhou, Andrew Ni, Ping Sun, Jia‐Jun Liu, Xin‐Lei Huang, Tian‐Qing Xiong, Yu‐Chi Zhang, Hai‐Zhou Liu, Xiao‐Tao Xu, Rui Wang, Shi‐Qing Zhang, Yu‐Xin Zhang, Silvia Liu, C. Edward Dixon, Jun Chen, Ke‐Jie Yin   +17 more
wiley   +1 more source