Results 31 to 40 of about 5,049,311 (291)

Percutaneous Osteotomy of the Tibial Tubercle: A Minimally Invasive Technique Assisted by Arthroscopy and Fluoroscopy

open access: yesArthroscopy Techniques
The tibial tubercle osteotomy (TTO) is a versatile technique that has historically been utilized to treat several disorders of the patellofemoral joint, including patellar instability, focal chondral defects, patellofemoral dysfunction, and arthritic ...
David Márquez, M.D.   +6 more
doaj   +1 more source

Sistema mecánico abre bolsas: un ejemplo práctico para la enseñanza

open access: yesNova Scientia, 2015
En este artículo se presenta la manera de obtener un modelo matemático simplificado de un sistema mecánico abre bolsas, con la finalidad de ejemplificar los conocimientos que se obtienen usualmente en el curso de dinámica de mecanismos, tales como ...
Ervin Jesús Alvarez Sánchez   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

El abastecimiento de fármacos a la región La Libertad en el quinquenio 2010 –2014

open access: yesINGnosis Revista de Investigación Científica, 2016
Objetivos. Analizar el abastecimiento de fármacos a la región La Libertad, en el quinquenio 2010 – 2014. Materiales y métodos. Esta investigación es aplicada o fáctica, explicativa y causal. Tiene un análisis mixto, predominantemente cuantitativo, pero con calificaciones o interpretaciones cualitativas. Resultados.
Walter Estela Tamay   +1 more
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Control Interno como generador de Valor Público: Diagnóstico y mejoras en el Servicio de Vivienda y Urbanización de la Región del Biobío, Chile

open access: yesGobierno y Administración Pública
El presente artículo busca diagnosticar la madurez del sistema de control interno del Serviu Biobío y proponer una matriz integrada –riesgo, calidad y supervisión– que optimice la planificación de controles.
Daniel Rodríguez Tapia   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

HACIA LA CONSOLIDACIÓN DE UN PROGRAMA REGIONAL DE ENSEÑANZA TERCIARIA EN LA REGIÓN ESTE DE URUGUAY [PDF]

open access: yes, 2014
El Centro Universitario de la Región Este (CURE) es un centro regional de la Universidad de la República (UdelaR) mayor institución de educación terciaria en Uruguay, que consta de tres sedes en los departamentos de la Región: Maldonado, Rocha y Treinta ...
Goñi, Ana Laura   +5 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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