Results 51 to 60 of about 5,510,993 (279)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

HACIA LA CONSOLIDACIÓN DE UN PROGRAMA REGIONAL DE ENSEÑANZA TERCIARIA EN LA REGIÓN ESTE DE URUGUAY [PDF]

, 2014
El Centro Universitario de la Región Este (CURE) es un centro regional de la Universidad de la República (UdelaR) mayor institución de educación terciaria en Uruguay, que consta de tres sedes en los departamentos de la Región: Maldonado, Rocha y Treinta ...
Goñi, Ana Laura, Cetrulo, Ricardo, Clemente, Juan, Pacheco, Juan Pablo, Lezama, Antonio, Delgado, Estela   +5 more
core  

Case report of an exercise training and nutritional intervention plan in a patient with A350P mutation in DES gene

Clinical Case Reports, 2020
Performing a supplementation intervention with creatine and protein, in conjunction with low‐intensity endurance and resistance exercise is safe and has a positive effect on the quality of life in a patient with desminopathy.
Camila Monje, Sebastian Jannas‐Vela, Keith Baar, Hermann Zbinden‐Foncea   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Evaluación del uso de una prueba rápida inmunocromatográfica en promotores de salud para el diagnóstico de la malaria en áreas rurales de la Amazonía peruana*

Revista Peruana de Medicina Experimental y Salud Pública, 2004
Objetivo: Evaluar la concordancia de los resultados obtenidos por promotores de salud de áreas rurales de la Amazonia peruana con los obtenidos por profesionales de laboratorio, al aplicar una prueba rápida inmunocromatográfica para el diagnóstico de la ...
César Cabezas S, Nancy Arróspide V, Wilmer Marquiño Q, Sonia Gutiérrez S, Ever Álvarez M, Jorge Chuquipiondo R, Tomasa Ruiz A, Martín Daza M, Gladys Chuquipiondo L   +8 more
doaj  

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

[Isabel Tenaille] [Material gráfico]: [(periodista)] [PDF]

, 1979
Ninguna foto indica autoríaContiene fotografías pertenecientes al archivo fotográfico del diario "Región", publicadas hacia ...
Diario Región (Oviedo)
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source