Results 41 to 50 of about 5,362,876 (283)
Arthroscopy TechniquesThe tibial tubercle osteotomy (TTO) is a versatile technique that has historically been utilized to treat several disorders of the patellofemoral joint, including patellar instability, focal chondral defects, patellofemoral dysfunction, and arthritic ...
David Márquez, M.D. +6 more
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Gobierno y Administración PúblicaEl presente artículo busca diagnosticar la madurez del sistema de control interno del Serviu Biobío y proponer una matriz integrada –riesgo, calidad y supervisión– que optimice la planificación de controles.
Daniel Rodríguez Tapia +2 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
HACIA LA CONSOLIDACIÓN DE UN PROGRAMA REGIONAL DE ENSEÑANZA TERCIARIA EN LA REGIÓN ESTE DE URUGUAY [PDF]
, 2014 El Centro Universitario de la Región Este (CURE) es un centro regional de la Universidad de la República (UdelaR) mayor institución de educación terciaria en Uruguay, que consta de tres sedes en los departamentos de la Región: Maldonado, Rocha y Treinta ...
Goñi, Ana Laura +5 more
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Revista mensual del Centro Región Leonesa: Revista mensual del Centro Región Leonesa - Año II Número 13 - 1920 mayo (01/05/1920) [PDF]
, 1920 Copia digital. Valladolid : Junta de Castilla y León.
Asociación Centro Región Leonesa (Buenos Aires)
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Revista mensual del Centro Región Leonesa: Revista mensual del Centro Región Leonesa - Año III Número 25 - 1921 noviembre (01/11/1921) [PDF]
, 1921 Copia digital. Valladolid : Junta de Castilla y León.
Asociación Centro Región Leonesa (Buenos Aires)
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