Results 91 to 100 of about 1,252,806 (307)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Regime-Switching Stochastic Volatility and Short-Term Interest Rates. [PDF]

open access: yes
In this paper, we introduce regime-switching in a two-factor stochastic volatility model to explain the behavior of short-term interest rates. The regime-switching stochastic volatility (RSV) process for interest rates is able to capture all possible ...
Raúl Susmel, Madhu Kalimipalli
core  

Dyktatura oczami kobiet. Analiza porównawcza Opowieści podręcznej Margaret Atwood i twórczości eseistycznej Herty Müller

open access: yesCreatio Fantastica, 2018
The article presents the results of a comparative analysis of Margaret Atwood’s The Handmaid’s Tale and essays written by Herta Müller, the most famous Romanian dissident and the recipient of the 2009 Noble Prize in literature.
Ewelina Feldman-Kołodziejuk
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Regime Switching and Artificial Neural Network Forecasting [PDF]

open access: yes
This paper provides an analysis of regime switching in volatility and out-of-sample forecasting of the Cyprus Stock Exchange using daily data for the period 1996-2002.
Robert Georgiades   +3 more
core  

Geomorphological insight into changing tectonic regime, Pasinler Basin, Turkey [PDF]

open access: yes, 2008
The Pasinler Basin, in the East Anatolian Contractional Province, features a suite of geomorphological zones, visible in the field, air photographs and Landsat and SRTM DEM imagery. These zones reflect past and current tectonically influenced processes.
Rust, DJ   +5 more
core   +1 more source

The Muslim Brotherhood: ¿A centrifugal or centripetal force?

open access: yesRevista CIDOB d'Afers Internacionals, 2011
Before the third Egyptian revolution in early 2011, the Muslim Brotherhood was considered the only real opposition capable of challenging the hegemonic government of the Egyptian regime, owing to the popular support the organisation enjoyed; much greater
Athina Lampridi-Kemou
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Constitucionalidade e análise crítica da contratação integrada prevista pelo Regime Diferenciado de Contratações Pública - RDC [PDF]

open access: yes, 2015
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Jurídicas. Direito.A presente monografia tem por objeto analisar a constitucionalidade e as críticas ao regime de execução da contratação integrada prevista pelo Regime ...
Garcia, Daniel Piccoli
core  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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