Results 131 to 140 of about 17,585,100 (417)

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

open access: yesMolecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu   +3 more
wiley   +1 more source

A New Rate Region for General Interference Channel (Improved HK Region) [PDF]

open access: yesarXiv, 2011
In this paper (a) after detailed investigation of the previous equivalent rate regions for general interference channel, i.e., the Han-Kobayashi (HK) and the Chong-Motani-Garg (CMG) regions, we define modified CMG region the equivalency of which with the HK region is readily seen; (b) we make two novel changes in the HK coding.
arxiv  

REGIONAL DISPARITIES IN CANADA: INTERPROVINCIAL OR URBAN/RURAL? [PDF]

open access: yes
The nature of regional disparities in Canada is analysed in this paper, with a focus on their interprovincial or urban/rural nature. Starting by presenting a traditional approach to regional disparities in Canada, we show that statistics indeed lead us ...
Pierre-Marcel DESJARDINS
core  

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Spatially Constrained Spectral Clustering Algorithms for Region Delineation [PDF]

open access: yesarXiv, 2019
Regionalization is the task of dividing up a landscape into homogeneous patches with similar properties. Although this task has a wide range of applications, it has two notable challenges. First, it is assumed that the resulting regions are both homogeneous and spatially contiguous.
arxiv  

REGIONAL DISPARITIES IN ITALY OVER THE LONG RUN: THE ROLE OF HUMAN CAPITAL AND TRADE POLICY [PDF]

open access: yes
The well known Italian dualism in terms of development disparities between the North and the South has been one of the most debated issues in economics over the last few decades.
Luisa GAGLIARDI, Marco PERCOCO
core  

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

open access: yesMolecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam   +2 more
wiley   +1 more source

EDUCATIONAL PERFORMANCE AND SPATIAL CONVERGENCE IN PERU [PDF]

open access: yes
While an enormous and growing literature exists on the topic of re-gional income convergence, other aspects of socioeconomic well-being and development have attracted much less attention. Social indicators are a valuable complement to economic indicators
Maribel ELIAS, Sergio J. REY
core  

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