Results 111 to 120 of about 14,433,678 (306)
Back Matter Vol. 18 No.2 (2023)
Region: Jurnal Pembangunan Wilayah dan Perencanaan Partisipatif, 2023 Jurnal Region
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MULTISCALAR CLUSTERS AND NETWORKS AS THE FOUNDATIONS OF INNOVATION DYNAMICS IN THE BIOPHARMACEUTICAL INDUSTRY [PDF]
Based on the case of the biopharmaceutical industry, the aim of this paper is to challenge the core conviction now widespread within the “spatial clustering theory”, which devotes a key (if not exclusive) role to geographical proximity in explaining ...
Abdelillah HAMDOUCH, Marc-Hubert DEPRET
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
REGIONAL AND URBAN SCIENCE IN FRANCE: RANKINGS OF AUTHORS AND INSTITUTIONS AND PUBLICATION PATTERNS DURING THE NINETIES [PDF]
This article analyses the evolution experienced by research in urban and regional science in France between 1991 and 2000, comparing these changes with wider international trends.
J. SURIÑACH +2 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
METROPOLITAN DEVELOPMENT AND COOPERATION IN SOUTH-EASTERN EUROPE [PDF]
This paper explores the role and importance of the four, closelocated, metropolises of south-eastern Europe (Skopje, Sofia, Thessaloniki and Tirana) and proposes a strategy that promotes metropolitan growth and development, maximizes spread effects to ...
George PETRAKOS, Paschalis ARVANITIDIS
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
THE ECONOMIC CONSEQUENCES OF FOREIGNER RULES IN NATIONAL SPORTS LEAGUES [PDF]
Profitable and balanced domestic league sports are among the central prerequisites for attracting the right to host a mega-event like the soccer world cup as well as for the overall economic success of such events.
Alexander RATHKE +2 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
SLIPPERY SLOPE ? ASSESSING THE ECONOMIC IMPACT OF THE 2002 WINTER OLYMPIC GAMES IN SALT LAKE CITY, UTAH [PDF]
This paper provides an empirical examination of the 2002 Winter Olympic Games in Salt Lake City, Utah. Our analysis of taxable sales in the counties in which Olympic events took place finds that some sectors such as hotels and restaurants prospered while
Robert A. BAADE +2 more
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