Results 51 to 60 of about 1,706,953 (315)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Energies, 2020 Renewable energy production is gaining importance in the context of global climate changes. However, in some countries other aspects increasing the role of renewable energy production are also present.
Adam Wąs +7 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Policy networking as capacity building: An analysis of regional road development conflict in Indonesia [PDF]
, 2010 This article explores the potential of policy networking as an important aspect of capacity building. It deals with a road development project related to the regional planning issue of North Bandung Area (NBA), a water catchment area facing the expansion
Woltjer, Johan +9 more
core +1 more source
CHANGES IN THE INCOMES AND EXPENDITURES OF HOUSEHOLDS IN POLAND AND THEIR REGIONAL RELATIONS
Polityki Europejskie, Finanse i Marketing, 2021 The article assesses the financial situation of households in 2000-2019 in prospect of changes of incomes and expenditures in Poland. It has been assumed, as a point of reference, that dispersionof the analysed processes is dependent on geographical ...
Beata Kasprzyk +1 more
doaj
Region of interest analysis for fMRI [PDF]
Social Cognitive and Affective Neuroscience, 2007 A common approach to the analysis of fMRI data involves the extraction of signal from specified regions of interest (or ROI's). Three approaches to ROI analysis are described, and the strengths and assumptions of each method are outlined.
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Talking Point: the missing migrants [PDF]
, 2016 Higher rates of population growth in our big cities are not driven by Australians moving from the regions to the city. Regional Australia has lower population growth than the cities because it does not attract its share of international migrants ...
Regional Australia Institute
core
The competitiveness of tourism in Romania after EU accession: Regional analysis [PDF]
Ekonomika Poljoprivrede (1979), 2019 Tourism is dependent on the existence of natural and antrophic resources. Because Romania is characterized by great variety and diversity of these type of resources, we want to study the evolution and attractiveness of tourism and how it was influenced ...
Rosu Elisabeta, Voicilas Dan-Marius
doaj