Results 61 to 70 of about 1,706,953 (315)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Regional Strategic Analysis and Knowledge Support System (ReSAKSS)

open access: yes, 2020
Regional strategic analysis and knowledge support system (ReSAKSS) is a Africa-focused database nodes that compile, analyze, and disseminate data, information, and tools to help design, implement, monitor, and evaluate rural development strategies.Non ...
Regional Strategic Analysis and Knowledge Support System (ReSAKSS)
core  

Desertification: On Significance of The Term and Research of The Phenomenon

open access: yesMiscellanea Geographica: Regional Studies on Development, 2006
First elaborations on desertification come from the Renaissance, but the term was used for the first time by Aubréville in 1949. In later years, many significantly varying in meaning definitions were elaborated.
Plit Florian
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Analytical validation of an automated assay to measure calprotectin (S100A8/A9) in dog saliva and serum and changes in canine leishmaniasis, pyometra and hyperadrenocorticism

open access: yesBMC Veterinary Research
Background Calprotectin (S100A8/A9) is a protein related to innate immunity that is considered a biomarker of inflammation. Currently, there is a commercially available automated assay for the measurement of calprotectin concentration (Bühlmann fCal ...
Marina García-Camacho   +4 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Issue analysis as a basis for sub-state regional role delineation. Working paper - State-Regional Land Use Task Force, University of Illinois ; no. 2

open access: yes, 1974
Made available in DSpace on 2011-11-21T22:17:21Z (GMT). No. of bitstreams: 2 issueanalysisasb02univ.pdf: 4228704 bytes, checksum: 2b79e6ac983c5826394c074300137ea2 (MD5) license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) Previous ...
University of Illinois at Urbana-Champaign. State-Regional Land Use Task Force
core  

THE REGIONAL ECONOMIC DEVELOPMENT PARADOX: ATTEMPTING POLICY ORDER IN THE FACE OF SOCIETAL COMPLEXITY [PDF]

open access: yes, 2017
Regional economic development, in its various guises and manifestations, is deployed throughout much of Australia. Whilst it remains a contested activity, the conventional wisdom of orthodox regional development practice extols the need to embrace ...
Pugalis, LC
core  

From H5N1 to HxNy: An epidemiologic overview of human infections with avian influenza in the Western Pacific Region, 2003–2017

open access: yesWestern Pacific Surveillance and Response, 2019
Since the first confirmed human infection with avian influenza A(H5N1) virus was reported in Hong Kong SAR (China) in 1997, sporadic zoonotic avian influenza viruses causing human illness have been identified globally with the World Health Organization ...
Sarah Hamid   +10 more
doaj   +1 more source

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