Results 61 to 70 of about 4,944,391 (290)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
The competitiveness of tourism in Romania after EU accession: Regional analysis [PDF]
Ekonomika Poljoprivrede (1979), 2019 Tourism is dependent on the existence of natural and antrophic resources. Because Romania is characterized by great variety and diversity of these type of resources, we want to study the evolution and attractiveness of tourism and how it was influenced ...
Rosu Elisabeta, Voicilas Dan-Marius
doaj
Inter-Regional Wage Differentials in Portugal: An Analysis Across the Wage Distribution [PDF]
, 2012 Typically, studies on regional wage differentials are based on ordinary least squares (OLS) estimates. Quantile regression is an alternative approach which allows these differences to be studied across the whole wage distribution.
Galego, Aurora, Pereira, João
core +2 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
BMC Veterinary ResearchBackground Calprotectin (S100A8/A9) is a protein related to innate immunity that is considered a biomarker of inflammation. Currently, there is a commercially available automated assay for the measurement of calprotectin concentration (Bühlmann fCal ...
Marina García-Camacho +4 more
doaj +1 more source
Desertification: On Significance of The Term and Research of The Phenomenon
Miscellanea Geographica: Regional Studies on Development, 2006 First elaborations on desertification come from the Renaissance, but the term was used for the first time by Aubréville in 1949. In later years, many significantly varying in meaning definitions were elaborated.
Plit Florian
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Azormod dynamic general equilibrium model for Azores [PDF]
, 2009 The main objective of this paper is to present a multi-sectoral, multi-regional dynamic modelling platform of the Azores economy integrated within the European and global context.
Bayar, Ali +4 more
core
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Regional Frequency Analysis [PDF]
, 2011 Regionalisation is a useful approach in dealing with data poor catchments. A set of catchment attributes are used to select hydrologically similar catchments in order to overcome the data shortage problem.
openaire +1 more source