Results 41 to 50 of about 9,187 (121)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Temporal Dissociation of Impaired Glucose Tolerance, Adipose Lipid Remodeling and Endothelial Dysfunction in Aorta After HFD Withdrawal

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
HFD withdrawal results in early restoration of systemic glucose tolerance and PVAT lipid unsaturation that is temporarily dissociated from the reversal of endothelial dysfunction in aorta that may be linked to altered PVAT function featured by impaired guanylate cyclase signaling pathway.
Krzysztof Czamara, Izabela Czyzynska‐Cichon, Anna Bar, Ewa Stanek, Mateusz Wawro, Marta Z. Pacia, Zeinep Berkimbayeva, Brygida Marczyk, Elvira Bragado‐García, Paloma Palma‐Guzman, Maria S. Fernandez‐Alfonso, Stefan Chlopicki   +11 more
wiley   +1 more source

Microfluidic Platform for Multiparametric Profiling of Fibrin Permeability, Fibrinolysis, and Cell Invasion

Advanced Functional Materials, Volume 36, Issue 37, 7 May 2026.
This paper introduces a single‐channel H‐junction microfluidic assay that profiles fibrin's evolving function in repair and thrombosis by measuring, in one ∼3 µL gel, permeability, fibrinolysis kinetics, fibroblast invasion, and clot extension in real time.
Halston Deal, Elizabeth M. Byrnes, Sanika Pandit, Halle J. Cantor, Muskan Aslam, Stacy Ban, Megan Palmisano, Rosemary Bayless, Ashley C. Brown, Michael Daniele   +9 more
wiley   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Early Detection of Acute and Early‐Onset Cancer Therapy‐Related Cardiac Dysfunction in Children With Cancer Using a Multiparametric Approach: Methodological Aspects of the EARLY Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Cancer therapy‐related cardiac dysfunction (CTRCD) is among the most important adverse effects of treatment of childhood cancer. In the EARLY study (Early detection of acute and early‐onset cARdiovascuLar toxicity in children with cancer using a multiparametric approach), cardiac function in children treated for cancer was monitored
Theodorus W. Kouwenberg, Heynric B. Grotenhuis, Leontien C. M. Kremer, Esmée C. de Baat, Auke Beishuizen, Max M. van Noesel, Livia Kapusta, Rutger A. J. Nievelstein, Birgitta K. Velthuis, Martijn G. Slieker, Tim Leiner, Bianca A. W. Hoeben, Annelies M. C. Mavinkurve‐Groothuis, Elizabeth A. M. Feijen   +13 more
wiley   +1 more source

Quantitative Assessment of Myocardial Perfusion in Physiological and Pathological Hypertrophy Using Myocardial Contrast Echocardiography

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Myocardial hypertrophy can be classified into physiological and pathological types based on etiology, with significant differences in clinical outcomes. This study utilized myocardial contrast echocardiography to quantitatively assess myocardial microcirculatory perfusion in patients with different types of hypertrophy.
Liu Chunyao, Jiang Ruihan, Li Kai, Lin Mingming, Wang Xiaofan, Lv Qifeng, Song Xiaoxia, Tian Yu, Sun Juanjuan, Sun Pin   +9 more
wiley   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

Left ventricular fibrosarcoma in a 4‐year‐old labrador

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 4‐year‐old, male, neutered labrador presented for investigations into a single episode of collapse and an intracardiac mass. Echocardiography and computed tomography confirmed the presence of a large soft tissue mass within the left ventricular lumen, which nearly obstructed the left ventricular outflow tract.
Natalia Caldecott, Radu Constantinescu, Catherine Ennett, Tsumugi Anne Kurosawa, David Brewer   +4 more
wiley   +1 more source

Cardiopulmonary arrest following extradural analgesia and suspected secondary sympathetic blockade in a critically ill dog

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract An 8‐year‐old, male, entire Cocker Spaniel presented to the Queen Mother Hospital for Animals for treatment of an iatrogenic septic uroabdomen secondary to traumatic urinary catheterisation. After initial stabilisation, it underwent diagnostic imaging and definitive surgical correction comprising a cystotomy and bladder reconstruction.
Joe Simon, Manuel Enrique Herrera‐Linares, Hannah Louise Matson, Cristina Bianchi   +3 more
wiley   +1 more source