Results 41 to 50 of about 9,474 (137)

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Multiscale mechanistic modelling of heterogeneity in cardiac sub‐cellular calcium handling accounting for variable t‐system density

The Journal of Physiology, EarlyView.
Abstract figure legend Illustration of spatial calcium dynamics (left panels) and the state cycle approximation (middle panel) that enables reduced simulation of spatially dependent dynamics without explicit description of space (right panels). The selected example here illustrates a spontaneous calcium wave, showing temporal snapshots of local calcium
Michael A Colman, Yohannes Shiferaw, David Conesa   +2 more
wiley   +1 more source

Characterizing Metabolic and Compositional Heterogeneity of Calf Muscle Using CEST MRI at 3 T

NMR in Biomedicine, Volume 39, Issue 8, August 2026.
This study used 3 T CEST MRI to characterize metabolic and compositional heterogeneity in eight healthy calf muscles, focusing on amide, PCr, rNOE, and MT contrasts. Distinct signatures emerged between deep stabilizer and superficial powerhouse muscles. Significant correlations with age, fat content, BMI, and strength (e.g., rNOE vs. strength) revealed
Huabin Zhang, Kangli Pi, Ziyan Wang, Fan Huang, Juan Wei, Patrick Liebig, Lin Chen, Yang Zhou, Yi Zhang, Varut Vardhanabhuti, Jianpan Huang   +10 more
wiley   +1 more source

Clinicopathological and molecular characterization of HPV‐associated cervical poorly cohesive carcinoma: a rare aggressive entity

The Journal of Pathology: Clinical Research, Volume 12, Issue 4, July 2026.
Abstract Primary signet‐ring cell carcinoma and poorly differentiated adenocarcinoma with poorly cohesive morphology in the cervix are rare conditions, and their clinicopathological features remain poorly described. This study defines primary cervical poorly differentiated adenocarcinomas meeting the diagnostic criteria for poorly cohesive carcinoma as
Wei Liu, Xiao‐jiang Wang, Yan‐mei Cui, Jing‐cheng Liu, Jiajie Zhang, Li‐bin Zhang, Xi Lei, Xiuqin Weng, Wucheng Shen, Wen‐xiu Miao, Jun‐cheng Ye, Tong‐mei He, Qin Xu, Yi Shi, Dan Hu   +14 more
wiley   +1 more source

Association of Global Longitudinal Strain With Left Ventricular Remodeling and Left Ventricular Hypertrophy in Patients With Acute Myocardial Infarction After PCI: A Small Single‐Center Prospective Observational Study

Health Science Reports, Volume 9, Issue 7, July 2026.
ABSTRACT Background and Aims Among patients with acute myocardial infarction undergoing PCI, subsequent structural alterations of the left ventricle, including left ventricular remodeling (LVR) and left ventricular hypertrophy (LVH), may contribute to later heart failure.
Bing Wang, Hong Yao, Zhijian Zhu, Zhigang Lu, Yesheng Pan   +4 more
wiley   +1 more source

Mesenteric Lymphatic Dysfunction as the Initiating Event in Crohn's Disease: Toward an Outside‐In Paradigm

JCC Plus, Volume 1, Issue 4, July 2026.
Mesenteric lymphatic dysfunction promotes immune cell accumulation and chronic inflammation, leading to creeping fat formation. Progressive activity drives transmural inflammation. ABSTRACT Crohn's disease (CD) has traditionally been explained by an “inside‐out” model, in which disruption of the intestinal mucosal barrier allows luminal bacteria to ...
Takayuki Ogino, Yuki Sekido, Tsunekazu Mizushima, Mitsunobu Takeda, Tsuyoshi Hata, Atsushi Hamabe, Norikatsu Miyoshi, Mamoru Uemura, Yuichiro Doki, Hidetoshi Eguchi   +9 more
wiley   +1 more source

Congenital Myopathies and Muscular Dystrophies: A Single Tertiary Center Experience and Factors Associated With Long‐Term Outcomes

Muscle &Nerve, Volume 74, Issue 1, Page 121-130, July 2026.
ABSTRACT Introduction/Aims Data on respiratory, feeding, ambulatory outcomes and prognostic factors for congenital myopathies (CM) and congenital muscular dystrophies (CMD) remain limited. Therefore, in this study, we report the characteristics of a large single‐center cohort of patients with CM and CMD, focusing on long‐term outcomes and aiming to ...
Can Ozlu, Margaret McGurn, Susan Iannaccone, Zurisadai Gonzalez Castillo, Kaitlin Batley   +4 more
wiley   +1 more source

The Molecular Diagnosis of Myopathies: Integrating Genomic, Proteomic, and Pathological Insights Toward Precision Medicine

Clinical Genetics, Volume 110, Issue 1, Page 15-28, July 2026.
Advances in genomic, proteomic, and transcriptomic technologies are transforming the diagnosis of genetic myopathies. When integrated with traditional muscle pathology, multi‐omics approaches improve diagnostic yield, clarify disease mechanisms, and support more precise, mechanism‐based therapeutic strategies for patients with neuromuscular disorders ...
Ludmila Alem, Denise de Abreu Pereira, Katia Carneiro   +2 more
wiley   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source