Results 151 to 160 of about 293,878 (305)

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

VEGETATION HOMOGENEOUS REGIONS USING NDVI VARIABILITY

, 2017
The classification techniques, such as cluster analysis, used in biological areas, in the plants and animals classification keys, are also useful for defining homogeneous regions, for climate data or for identification or monitoring of vegetation.
Cordeiro, Ana Paula Assumpção, Berlato, Moacir Antônio, Fontana, Denise Cybis, Melo, Ricardo Wanke de, Shimabukuro, Yosio Edemir, Fior, Claudimar Sidnei   +5 more
openaire   +1 more source

GloPath: An Entity‐Centric Foundation Model for Glomerular Lesion Assessment and Clinicopathological Insights

Advanced Science, EarlyView.
An entity‐centric foundation model, GloPath, is introduced for comprehensive glomerular lesion assessment from routine renal biopsy images. Trained on over one million glomeruli, the framework enables robust lesion recognition, grading, and cross modality diag nosis, while uncovering large‐scale clinicopathological associations.
Qiming He, Jing Li, Tian Guan, Yifei Ma, Zimo Zhao, Yanxia Wang, Hongjing Chen, Yingming Xu, Shuang Ge, Yexing Zhang, Yizhi Wang, Xinrui Chen, Lianghui Zhu, Yiqing Liu, Qingxia Hou, Shuyan Zhao, Xiaoqin Wang, Lili Ma, Peizhen Hu, Qiang Huang, Zihan Wang, Zhiyuan Shen, Junru Cheng, Siqi Zeng, Jiurun Chen, Zhen Song, Chao He, Zhe Wang, Yonghong He   +28 more
wiley   +1 more source

Intermittent energy restriction changes the regional homogeneity of the obese human brain. [PDF]

Front Neurosci, 2023
Li Z, Wu X, Gao H, Xiang T, Zhou J, Zou Z, Tong L, Yan B, Zhang C, Wang L, Wang W, Yang T, Li F, Ma H, Zhao X, Mi N, Yu Z, Li H, Zeng Q, Li Y.   +19 more
europepmc   +1 more source

Identification of homogeneously staining regions in leukemia patients.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2013
Homogeneously staining regions (HSR) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplification in a variety of cancers. The diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics.
Mohammad Heydarian Moghadam, Abolfazl Movafagh, MirDavood Omrani, Kiandokht Ghanati, Mehrdad Hashemi, Farhikhteh Poursafavi, Hossein Darvish, Davood Zare Abdolahi, Milad Gholami, Mohammad Reza Heidari Rostamy, Shamsi Safari, Leyla HaghNejad, Reyhaneh Darehgazani, Niloofar Safavi Naeini, Mehdi Ghandehari Motlagh, Davar Amani   +15 more
openaire   +2 more sources

Corals and Reef‐Dwelling Fish Regulate Carbon Storage and Cycling Processes in Coral Reef Ecosystems

Advanced Science, EarlyView.
Coral reefs are biodiversity hotspots, yet their role in carbon storage and cycling remains poorly understood. Using field surveys and modeling in the South China Sea, we reveal the overlooked potential of carbon storage in reef ecosystems and how reef fish, corals, and surface sediment jointly shape reef carbon reservoirs.
Yiting Chen, Wenliang Zhou, Lan Qiu, Han Lai, Mingpan Huang, Qian Li, Wen Yu, Pei‐Yuan Qian, Fuwen Wei   +8 more
wiley   +1 more source

Identifying major depressive disorder with associated sleep disturbances through fMRI regional homogeneity at rest. [PDF]

BMC Psychiatry, 2023
Lv D, Ou Y, Xiao D, Li H, Liu F, Li P, Zhao J, Guo W.   +7 more
europepmc   +1 more source

Economic Regions Based on the Agglomeration Economics: an Evaluation for the Spanish Case. [PDF]

What is region? From an economic point of view, a region is a unit in which capital and labour move freely and goods and services are totally open to trade with other regions without any frontiers or limitations.
Ana Viñuela, Fernando Rubiera Morollon   +1 more
core  

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Oil‐Coated Nanoplastics Induce Rapid Membrane Disruption and Severe Intestinal Injury

Advanced Science, EarlyView.
Oil‐rich food contact dramatically amplifies MNP release from plastic takeout containers, producing oil‐coated nanoplastics with altered surface properties and rapid membrane‐disruptive effects. These particles cause severe intestinal barrier damage and immune dysfunction in mice, and risk modeling suggests that long‐term gastrointestinal burdens may ...
Ruwen Xie, Gulimire Yilihan, Qiong Chen, Dachuan Lin, Zhen Liu, Mengyi Yuan, Yujia Wang, Haoteng Xu, Weishang Zhou, Wanxin Gong, Yueer Li, Chen Peng, Tong Yang, Peng Gao, Qing Liu, Xin‐Hua Feng, Mu Xiao, Chao Jiang   +17 more
wiley   +1 more source