Results 131 to 140 of about 66,811 (263)

Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models

Advanced Science, EarlyView.
A developmentally guided protocol reproducibly specifies EN1‐positive ventral midbrain dopaminergic (vmDA) progenitors from human pluripotent stem cells and yields functional vmDA neurons. Optogenetic induction of α‐synuclein aggregation elicits selective degeneration of TH‐positive neurons in 2D cultures and 3D neurospheroids, while transplanted ...
Heechang Moon, Heejeong Kim, Elliot H. Lee, Hanseul Kim, Ji Hun Kim, Huisu Jeong, Jiwon Cheon, Ga Ram Jeong, Byoung Dae Lee, Jae‐Won Cho, Soo‐Jin Oh, Yunjong Lee, Yohan Oh   +12 more
wiley   +1 more source

Altered regional homogeneity in Parkinson's disease with mild cognitive impairment: a resting-state fMRI study. [PDF]

Front Psychol
Zhu X, Zhou J, Wei Q, Pu H, Chen Y, Zhu X, Li B, Liu S.   +7 more
europepmc   +1 more source

Intermittent energy restriction changes the regional homogeneity of the obese human brain. [PDF]

Front Neurosci, 2023
Li Z, Wu X, Gao H, Xiang T, Zhou J, Zou Z, Tong L, Yan B, Zhang C, Wang L, Wang W, Yang T, Li F, Ma H, Zhao X, Mi N, Yu Z, Li H, Zeng Q, Li Y.   +19 more
europepmc   +1 more source

Morphology‐Defined Entropy Streams for Random‐Bit Generation and Probabilistic Sampling in Memristor Arrays

Advanced Science, EarlyView.
Au nanoisland morphology defines stochastic high‐resistance‐state transport in Ag/TiO2 memristor arrays, transforming nanoscale structural disorder into a tunable physical entropy resource. Morphology‐controlled field hotspots and reset‐modulated nanogaps generate statistically validated random‐bit streams, which further serve as device‐derived ...
Hyunjun Kim, Da Ye Kim, Noah Jang, Yongho Lee, Byunghun Song, June Soo Kim   +5 more
wiley   +1 more source

Dual Randomness From Spatial and Temporal Variations in Stochastic Zinc Gallate Nanoclusters for PUF and TRNG Co‐Driven Image Generation

Advanced Science, EarlyView.
A dual‐randomness hardware platform is demonstrated by integrating PUF and TRNG functionalities into mixed‐ZGO nanoclusters. By leveraging spatial and temporal stochasticity, the mixed‐ZGO NCs device enables both unique identification and random signal generation.
Seungme Kang, Wangmyung Choi, Jueun Lee, Yeong Kwon Kim, Byung Chul Jang, Wonjun Shin, Hocheon Yoo   +6 more
wiley   +1 more source

Identifying neurophenotypes of major depressive disorder through normative model of regional homogeneity. [PDF]

Transl Psychiatry
Luo Z, Li W, Xu Y, Shen J, Wang C, Lan X, Liu G, Luo Z, Hou Z, Mai S, Zhang M, Sun X, Lu H, Zhou Y, Ning Y.   +14 more
europepmc   +1 more source

Identifying major depressive disorder with associated sleep disturbances through fMRI regional homogeneity at rest. [PDF]

BMC Psychiatry, 2023
Lv D, Ou Y, Xiao D, Li H, Liu F, Li P, Zhao J, Guo W.   +7 more
europepmc   +1 more source

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

Advanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu, Jiachen Wang, Chunmeng Ding, Changfa Xia, Yunyong Liu, Yuanjie Zheng, Sheng Chang, Shaokai Zhang, Yutong He, Ruifang Sun, Yunfeng Xi, Yan Liu, Kun Qian, Wanqing Chen   +13 more
wiley   +1 more source

Altered static and dynamic regional homogeneity in basal ganglia-thalamocortical circuits and their association with neuropsychiatric manifestations in Wilson's disease. [PDF]

Front Neurosci
Zhou Z, Xiao W, Yang N, Lin W, Chen Z, Liang M, Li J, Wu Y.   +7 more
europepmc   +1 more source

Temporal Dynamic Alterations of Regional Homogeneity in Parkinson's Disease: A Resting-State fMRI Study. [PDF]

Biomolecules, 2023
Li K, Tian Y, Chen H, Ma X, Li S, Li C, Wu S, Liu F, Du Y, Su W.   +9 more
europepmc   +1 more source