Results 121 to 130 of about 66,811 (263)

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Posture-Related Regional Homogeneity Abnormalities in Cerebral Small Vessel Disease: A Multi-Position MRI Study. [PDF]

CNS Neurosci Ther
Zhang Y, Dai Q, Fan W, Yu H, Hu L, Fan S, Ni L, Ma D, Wang D, Surento W, Zhang X, Qi R, Zheng J, Zhang B.   +13 more
europepmc   +1 more source

Modulation of the TGF‐β/Smad Signaling Pathway by a Bioactive Oxidized Polygonati Rhizoma Polysaccharide Crosslinked Chitosan Hydrogel as Therapeutic Carrier for Parkinson's Disease Treatment

Advanced Science, EarlyView.
An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai, Jikuang Zhao, Chang Xue, Kailei Xu, Liang Yong, Zhuangwei Zhang, Yi Huang, Jianwei Shuai, Xianzhen Chen, Sheng Nie, Junpeng Xu   +10 more
wiley   +1 more source

Sex-Related Differences in Regional Homogeneity and Intolerance of Uncertainty in Obsessive-Compulsive Disorder: A Resting-State fMRI Study. [PDF]

Neuropsychiatr Dis Treat
Wang A, Zhao S, Guo Q, Wu J, Fang W, Zheng S, Zhu C, Zhang X.   +7 more
europepmc   +1 more source

Covert Optical Fingerprints Within Overt Structural Colors via Cascaded Cavity Resonances

Advanced Science, EarlyView.
Cascaded photonic–plasmonic cavities combine vivid structural colors with hidden stochastic optical fingerprints in a single monolithic platform. Layered cavities control the overt appearance, while disordered nanogap resonances generate covert scattering with limited mutual influence.
Gyurin Kim, Jiyeong Ma, Juhwan Kim, JuHyeong Lee, Heungchan Kwon, Young Min Song, Hyeon‐Ho Jeong   +6 more
wiley   +1 more source

An exploratory study of altered regional homogeneity in Parkinson's disease with depression. [PDF]

Front Psychiatry
Liu S, Zhu X, Chen Y, Zhang C, Zhu X, Zhang R, Chen L, Li B, Zhong P.   +8 more
europepmc   +1 more source

GSLR Drives Lung Adenocarcinoma as a Critical Regulator of Energy Homeostasis Through Creatine Kinase B Activation

Advanced Science, EarlyView.
This study identifies the glucose/glutamine sensitive lncRNA GSLR as a driver of lung adenocarcinoma progression. Nutrient restriction reduces chromatin accessibility at the GSLR locus and blocks CTCF‐mediated transcriptional regulation. GSLR directly interacts with DHX9 and recruits it to the CKB promoter, arresting R‐loop accumulation and promoting ...
Xinyi Qian, Juze Yang, Jiayi Ren, Xiaowei Mao, Jia Li, Tengfei Sun, Liangliang Dong, Enguo Chen, Yan Lu, Pengyuan Liu   +9 more
wiley   +1 more source

Transdiagnostic mapping of common and specific regional homogeneity alterations across affective and psychotic disorders. [PDF]

Neuropsychopharmacology
Xiang J, Ran J, Zhu P, Wang Y, Deng X, Yang B, Zhang L, Chen X, Guo J, Liu J, Qin K, Chen W.   +11 more
europepmc   +1 more source

Regional homogeneity and functional connectivity of freezing of gait conversion in Parkinson's disease. [PDF]

Front Aging Neurosci, 2023
Bao Y, Ya Y, Liu J, Zhang C, Wang E, Fan G.   +5 more
europepmc   +1 more source