Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Modelling regional economic effects of the Öresund link -linking two regional economic models [PDF]
The Öresund link, opened in July 2000, is a sixteen-kilometre fixed link with several specific characteristics. E.g., the link connects two countries, Denmark and Sweden and two urban areas, Copenhagen and Malmö, with 1 and 0,5 million people ...
Anderstig, Christer, Andersen, Anne Kaag
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Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source
The Future of Regional Australia: Change on Our Terms
Government has diminishing control over the factors that shape Australia's regions. Such factors include the global economy, technological change, the environment and population.
Sorensen, Tony
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Prosperous futures: understanding the potential of Australia’s regional cities [PDF]
This paper explores the connection between the competitive advantage of a region and actual growth experienced. Summary The connection between the competitive advantage of a region and actual growth experience is complex.
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RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
MODELING OF RESOURCE FLOWS IN THE REGION
The urgency of the topic of the study is obvious, since any structural changes taking place at the regional level have an impact on the nature of the flow of resources, on the level of social and economic development of the region, and, accordingly, on the level of its economic security.
Volodymyr Proskura, Olena Maksiutova
openaire +2 more sources
The Perception of issues by sub-state regions. Working paper - State-Regional Land Use Task Force, University of Illinois ; no.1 [PDF]
Made available in DSpace on 2011-11-21T22:23:58Z (GMT). No. of bitstreams: 2 perceptionofissu01univ.pdf: 4217922 bytes, checksum: 19aa9aed34445ace56fbe7ddd108a021 (MD5) license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) Previous ...
University of Illinois at Urbana-Champaign. State-Regional Land Use Task Force
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