Results 91 to 100 of about 4,328,763 (308)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

open access: yesFEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell   +8 more
wiley   +1 more source

Modelling regional economic effects of the Öresund link -linking two regional economic models [PDF]

open access: yes, 2001
The Öresund link, opened in July 2000, is a sixteen-kilometre fixed link with several specific characteristics. E.g., the link connects two countries, Denmark and Sweden and two urban areas, Copenhagen and Malmö, with 1 and 0,5 million people ...
Anderstig, Christer, Andersen, Anne Kaag
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Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi   +8 more
wiley   +1 more source

The Future of Regional Australia: Change on Our Terms

open access: yes, 2017
Government has diminishing control over the factors that shape Australia's regions. Such factors include the global economy, technological change, the environment and population.
Sorensen, Tony
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Prosperous futures: understanding the potential of Australia’s regional cities [PDF]

open access: yes, 2014
This paper explores the connection between the competitive advantage of a region and actual growth experienced. Summary The connection between the competitive advantage of a region and actual growth experience is complex.

core  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons   +33 more
wiley   +1 more source

MODELING OF RESOURCE FLOWS IN THE REGION

open access: yesScientific Bulletin of Mukachevo State University. Series “Economics”, 2018
The urgency of the topic of the study is obvious, since any structural changes taking place at the regional level have an impact on the nature of the flow of resources, on the level of social and economic development of the region, and, accordingly, on the level of its economic security.
Volodymyr Proskura, Olena Maksiutova
openaire   +2 more sources

The Perception of issues by sub-state regions. Working paper - State-Regional Land Use Task Force, University of Illinois ; no.1 [PDF]

open access: yes, 1974
Made available in DSpace on 2011-11-21T22:23:58Z (GMT). No. of bitstreams: 2 perceptionofissu01univ.pdf: 4217922 bytes, checksum: 19aa9aed34445ace56fbe7ddd108a021 (MD5) license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) Previous ...
University of Illinois at Urbana-Champaign. State-Regional Land Use Task Force
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