Results 71 to 80 of about 4,328,763 (308)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Would the occurrence of a Maunder-like solar minimum reverse the observed climate change?

Evolving Earth
This study examines a scenario combining a prolonged solar minimum, like the historical Maunder Minimum, with the increased CO2 emissions characteristic of the industrial era.
Marcio Cataldi, Rafael Rangel, Vitor Luiz Victalino Galves, Sonia Jerez, Juan Pedro Montávez, Amar Halifa-Marín, Luiz Landau   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Large increase in extreme fire weather synchronicity over Europe

Environmental Research Letters
Synchronous extreme fire weather can significantly increase the probability of fire ignition and spread, posing compounding threats to fire management efforts and potentially overwhelming firefighting capabilities.
Miguel Ángel Torres-Vázquez, Francesca Di Giuseppe, Alberto Moreno-Torreira, Andrina Gincheva, Sonia Jerez, Marco Turco   +5 more
doaj   +1 more source

Mapping long-term urban–rural sprawl trajectories at 100 m spatial resolution: Austria’s transition from low to high sprawl, 1975–2020

Journal of Land Use Science
Urban sprawl—the decentralization of housing, employment, and economic activities into scattered, low-density settlement patterns—poses a major challenge to achieving SDG 11: Sustainable cities and communities. Yet, its long-term development trajectories
Anna-Katharina Brenner, Tobias Krüger, Helmut Haberl, Gernot Stöglehner, Martin Behnisch   +4 more
doaj   +1 more source

Issue analysis as a basis for sub-state regional role delineation. Working paper - State-Regional Land Use Task Force, University of Illinois ; no. 2 [PDF]

, 1974
Made available in DSpace on 2011-11-21T22:17:21Z (GMT). No. of bitstreams: 2 issueanalysisasb02univ.pdf: 4228704 bytes, checksum: 2b79e6ac983c5826394c074300137ea2 (MD5) license.txt: 4922 bytes, checksum: 910b249b4beec47e7ab768910c8f966f (MD5) Previous ...
University of Illinois at Urbana-Champaign. State-Regional Land Use Task Force
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Air pollution and Type 2 Diabetes in Europe: Insights from nonlinear exposure–response modelling

Ecotoxicology and Environmental Safety
Air pollution is currently one of the major environmental problems related to human health, affecting many diseases. In this regard, while studies have established an association between air quality and Type 2 Diabetes Mellitus (T2DM), there is still a ...
Pedro Jiménez-Guerrero, Agustín Ríos-Moreno, Patricia Tarín-Carrasco   +2 more
doaj   +1 more source

Regional flood modelling in the new Australian Rainfall and Runoff

, 2013
This paper presents the regional flood estimation model being developed for the 4th edition of Australian Rainfall and Runoff (ARR). This covers the basic steps in the adopted modelling framework i.e. data collation, formation of regions, model form, and
Rahman, Ataur (R9573), Haddad, Khaled (R13960), Rahman, Ayesha S. (R17657)   +2 more
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source