Results 51 to 60 of about 125,448 (318)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Modelling inter-regional trade flows: data and methodological issues in Rhomolo [PDF]

, 2010
The present paper studies the modelling of inter-regional trade flows in the newly developed general equilibrium model of European Commission, Rhomolo.
Kancs, D'Artis, Stelder, Dirk, Ivanova, Olga   +2 more
core  

The Impact of Farming Mitigation Measures on Ammonia Concentrations and Nitrogen Deposition in the UK

Atmosphere
Ammonia (NH3) is an important precursor to airborne fine particulate matter (PM2.5) which causes significant health issues and can significantly impact terrestrial and aquatic ecosystems through deposition.
Matthieu Pommier, Jamie Bost, Andrew Lewin, Joe Richardson   +3 more
doaj   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

FEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino, Giuliana Fusco, Alfonso De Simone   +2 more
wiley   +1 more source

Improving hydrological and vegetation modelling using regional model calibration schemes together with remote sensing data [PDF]

, 2016
Remotely sensed data are widely used for estimating hydrological variables, such as land surface soil moisture, land surface evapotranspiration and catchment runoff because they provide temporally dynamic and spatially explicit information on land ...
Van Dijk, Albert, Zhang , Yongqiang, Chiew, F.H.S., Viney, Neil, Liu, Yanyan   +4 more
core  

The CMR model of moving regions [PDF]

Proceedings of the 5th ACM SIGSPATIAL International Workshop on GeoStreaming, 2014
Many natural phenomena can be nicely represented by concepts of moving regions. For example, hurricanes, rain clouds, pollution zones, etc., change shape and position over time. Current models of moving regions have proven to be difficult to translate effectively to implementation for two reasons: i) algorithms for operations, such as intersection, are
Mark McKenney, Sarita C. Viswanadham, Elizabeth Littman   +2 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Modelling Inflation in China - A Regional Perspective [PDF]

SSRN Electronic Journal, 2007
Abstract We model provincial inflation in China during the reform period. In particular, we are interested in the ability of the hybrid New Keynesian Phillips Curve (NKPC) to capture the inflation process at the provincial level. The study highlights differences in inflation formation and shows that the NKPC provides a reasonable description of the ...
Mehrotra, Aaron N., Peltonen, Tuomas A., Santos Rivera, Alvaro   +2 more
openaire   +5 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Modelling regional economic effects of the Öresund link -linking two regional economic models [PDF]

, 2001
The Öresund link, opened in July 2000, is a sixteen-kilometre fixed link with several specific characteristics. E.g., the link connects two countries, Denmark and Sweden and two urban areas, Copenhagen and Malmö, with 1 and 0,5 million people ...
Anderstig, Christer, Andersen, Anne Kaag
core