Results 61 to 70 of about 760,822 (314)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
AtmosphereThe primary goal of this study is to introduce the initial phase of developing an impact-based forecasting system for extreme heatwaves, utilizing a novel multivariate index which, at this early stage, already employs a combination of a statistical ...
Marcio Cataldi +7 more
doaj +1 more source
On proximity and hierarchy : exploring and modelling space using multilevel modelling and spatial econometrics [PDF]
, 2009 Spatial econometrics and also multilevel modelling techniques are increasingly part of the regional scientists‟ toolbox. Both approaches are used to model spatial autocorrelation in a wide variety of applications. However, it is not always clear on which
Parenti, Angela, Vanoutrive, Thomas
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Would the occurrence of a Maunder-like solar minimum reverse the observed climate change?
Evolving EarthThis study examines a scenario combining a prolonged solar minimum, like the historical Maunder Minimum, with the increased CO2 emissions characteristic of the industrial era.
Marcio Cataldi +6 more
doaj +1 more source
Modelling of Regional Economy Growth Strategy
Управленческие науки, 2017 Introduction, Purpose. Management of the regional economy development is experiencing rather serious methodological and instrumental difficulties. The diversified institutional constraints, private ownership of the companies do not allow constructively ...
I. S. Mezhov, E. V. Kletskova
doaj +1 more source
Matrix Representation of the Kaliningrad Regional Accounts System: Experimental Development and Modelling Prospects [PDF]
Балтийский регион, 2015 This article addresses the task of creating a regional Social Accounting Matrix (SAM) in the Kaliningrad region. Analyzing the behavior of economic systems of national and sub-national levels in the changing environment is one of the main objectives of ...
Soldatova S., Voloshenko K., Ogneva N.
doaj +1 more source