Results 61 to 70 of about 125,448 (318)
Neural network modelling of regional innovation ecosystems
Journal of New Economy, 2021 The emerging innovation-based economy, intense competition, rapid technological change combined with the need to perform business analysis of huge data flows, make it increasingly important to introduce new effective approaches to regional development ...
Elena N. Letiagina, Valentina I. Perovа
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Large increase in extreme fire weather synchronicity over Europe
Environmental Research LettersSynchronous extreme fire weather can significantly increase the probability of fire ignition and spread, posing compounding threats to fire management efforts and potentially overwhelming firefighting capabilities.
Miguel Ángel Torres-Vázquez +5 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Prosperous futures: understanding the potential of Australia’s regional cities [PDF]
, 2014 This paper explores the connection between the competitive advantage of a region and actual growth experienced. Summary The connection between the competitive advantage of a region and actual growth experience is complex.
core
AtmosphereThe primary goal of this study is to introduce the initial phase of developing an impact-based forecasting system for extreme heatwaves, utilizing a novel multivariate index which, at this early stage, already employs a combination of a statistical ...
Marcio Cataldi +7 more
doaj +1 more source
Laboratory models of regional chemotherapy
International Journal of Hyperthermia, 2008 Development of new treatment strategies and agents is a difficult and costly matter in oncology. Routinely drugs are tested in vitro on tumor cells which, however, may have limited predictive value for their activity in patients. Also, the pharmacokinetic behavior, intratumoral distribution, as well as toxic side effects, binding to other compounds and
ten Hagen, Timo, Eggermont, Lex
openaire +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Would the occurrence of a Maunder-like solar minimum reverse the observed climate change?
Evolving EarthThis study examines a scenario combining a prolonged solar minimum, like the historical Maunder Minimum, with the increased CO2 emissions characteristic of the industrial era.
Marcio Cataldi +6 more
doaj +1 more source
Modelling of Regional Economy Growth Strategy
Управленческие науки, 2017 Introduction, Purpose. Management of the regional economy development is experiencing rather serious methodological and instrumental difficulties. The diversified institutional constraints, private ownership of the companies do not allow constructively ...
I. S. Mezhov, E. V. Kletskova
doaj +1 more source