Results 41 to 50 of about 834,286 (302)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
SCIENCE-POLICY INTERFACE IN REGIONAL ENVIRONMENTAL MANAGEMENT: CASE OF HELCOM IN THE BALTIC CONTEXT
Соціальна економіка, 2023 The regional environmental cooperation in the Baltic Sea is the leading and “forerunner” model for managing environmental challenges at the regional level.
Uyanga Tsenddorj, Buyandelger Doljin
doaj +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Regional science at the turn of the century: Reflections on its epistemological status [PDF]
, 1998 As a contribution to the current debate on the state-of-the art of regional science, this paper presents some reflections on the epistemological and methodological status of the discipline as we approach the turn of the century.
Rabino, Giovanni A., Spence, Angela
core
Regional science: Directions for the future
Papers in Regional Science, 2004 Academic disciplines evolve and regional science is no exception. Physics, French or economics changes over time but at the end of the day (or decade), they remain physics, French or economics. But regional science is different; it can take on the perspectives of geography, economics, planning, or other social sciences.
Bailly, Antoine Sylvain, Gibson, Lay
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Contemporary Regional Studies – Theory, Methodology and Practice
Studia Regionalne i Lokalne, 2006 The paper offers a review of the evolution in defining and describing regions, showing mutual relationships between particular approaches and logical succession between various analytical concepts of the region.
Iwona Sagan
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Terminological Traps for Russian Bilingual Scientists
Polylinguality and Transcultural PracticesThis study addresses the issue of terminological pitfalls encountered by Russian bilingual scholars working in the field of linguoculturology and other humanities disciplines.
Chimiza K. Lamazhaa
doaj +1 more source