Results 61 to 70 of about 45,110,513 (323)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Methodology of Research Discourse
Сравнительная политика, 2015 The section is devoted to the comparative analysis of Russian and foreign Oriental studies, their similarities and differences, as well as to the analysis of the methodology used by historians and political scientists in the study of modern political ...
Alexei Dmitrievich Voskressenski +3 more
doaj
Сравнительная политика, 2015 The paper is intended to answer the question about the necessity to distinguish between various approaches to reconstruction of interdisciplinarity of regional studies within the scientific and educational fields.
Olga Zinevich
doaj +1 more source
Baltic Region, 2020 Given the unique diversity of Russian regions, regional studies are becoming particularly important for ensuring the stability and development of Russia.
Simonyan R. H., Slutskin L. N.
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Case-srufy: East Asia in World Political and Economic Processes
Сравнительная политика, 2015 The purpose of the section is to analyze the latest developments in the military and political sphere in East Asia, taking into account a wide range of challenges.
Kseniia Aleksandrovna Efremova +1 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source