Results 51 to 60 of about 4,539,160 (346)
Game Stud., 2016 In the last few years there has been an increase in game scholarship conducted in and focussed on areas outside of Western Europe and North America. This scholarship has been recognized and supported by the establishment of regional research networks and regular regional conferences, and has been collected in edited books and journal special issues ...
Liboriussen, Bjarke, Martin, Paul
openaire +3 more sources
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Methodology of Research Discourse
Сравнительная политика, 2015 The section is devoted to the comparative analysis of Russian and foreign Oriental studies, their similarities and differences, as well as to the analysis of the methodology used by historians and political scientists in the study of modern political ...
Alexei Dmitrievich Voskressenski +3 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Baltic Region, 2020 Given the unique diversity of Russian regions, regional studies are becoming particularly important for ensuring the stability and development of Russia.
Simonyan R. H., Slutskin L. N.
doaj +1 more source
, 2017 Regional studies are right in the center of scientific and political discourse at the moment; regional issues acquire special significance in the countries with a transition economy. However, there is still no clear definition of the term “region”.
Kochetkov, D. M., Vukovic, D.
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
“Policy scepticism” and the impact of Scottish Higher Education Institutions (HEIs) on their host region: accounting for regional budget constraints under devolution [PDF]
, 2010 A “policy scepticism” has emerged that challenges the results of conventional regional HEI impact analyses. Its denial of the importance of the expenditure impacts of HEIs appears to be based on a belief in either a binding regional resource constraint ...
Hermannsson, Kristinn +3 more
core +1 more source
The regional distribution of unemployment: What do micro-data tell us? [PDF]
, 2012 Regional disparities in unemployment rates are large and persistent. The literature provides evidence of their magnitude and evolution, as well as evidence of the role of certain economic, demographic and environmental factors in explaining the gap ...
López Bazo, Enrique +1 more
core +1 more source