Results 51 to 60 of about 92,548 (306)
Tumor mutational burden as a determinant of metastatic dissemination patterns
Molecular Oncology, EarlyView.This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
“No Regionalism” – Outlining the New Brazilian Commercial Policy
Comillas Journal of International Relations, 2017 This article aims elaborate an overview of the Latin American Regionalism schools of Latin American regionalism since the years 1960, culminating in a prospective analysis about the tendencies in terms of economic integration of the current Brazilian ...
Marcos Antônio Fávaro Martins +2 more
doaj +1 more source
Regional Cooperation in South Asia: Exploring the Three Pillars of Regionalism and their Relevance
The Journal of Indian and Asian Studies, 2020 The lofty ideals penned by the heads of the South Asian states at the birth of the South Asian Association for Regional Cooperation (SAARC) reflect a vision for promoting mutual trust and understanding in South Asia.
ADITI PAUL
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Latin American Regionalism in the Agenda of International Relations Theory
Iberoamericana. América Latina - España - Portugal, 2016 This paper is based on the assumption that Latin America has been a pioneer in thinking about itself as a region, even before any European integration attempt took place.
Melisa Deciancio
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Mobility Case for Regionalism [PDF]
, 2013 In the discourse of local government law, the idea that a mobile populace can “vote with its feet” has long served as a justification for devolution and decentralization.
Davidson, Nestor M., Foster, Sheila R.
core +2 more sources
South Asian Integration Prospects and Lessons from East Asia [PDF]
In the context of the low levels of regional cooperation among South Asian countries when compared with the successful results from cooperation in East Asia (consisting of South East and East Asian countries), the objective of this paper is first to ...
Rajiv Kumar, Ramesh Chandra
core +4 more sources
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Competitiveness and sustainability: can ‘smart city regionalism’ square the circle? [PDF]
Increasingly, the widely established, globalisation-driven agenda of economic competitiveness meets a growing concern with sustainability. Yet, the practical and conceptual co-existence—or fusion—of these two agendas is not always easy.
Castells M. +10 more
core +1 more source