Results 61 to 70 of about 92,548 (306)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Фінансово-кредитна діяльність: проблеми теорії та практикиThe article examines the features of the application of correlation-regression analysis to identify the impact of state health prevention financing programs on the activities of health protection entities in Ukraine.
Raisa Nikitenko +4 more
doaj +1 more source
Clubs within clubs: The Council of the Baltic Sea States (CBSS) and the Benelux as Macro-regions within the EU [PDF]
, 2011 This paper deals with two examples of macro-regions in the EU: the Benelux and the Council of the Baltic Sea States (CBSS). Building on the distinction between “old” and “new” regionalism, it discusses some characteristics of regions in general, and of ...
Groenendijk, Nico
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Nitrogen Eutrophication in Chinese Aquatic Ecosystems: Drivers, Impacts, and Mitigation Strategies
NitrogenNitrogen eutrophication represents a significant environmental challenge in Chinese aquatic ecosystems, exacerbated by rapid agricultural intensification, industrial expansion, and urban development.
Armstrong Ighodalo Omoregie +3 more
doaj +1 more source
Regional Government and Regional Planning in the Hanover Region [PDF]
Quaestiones Geographicae, 2014 Abstract The Hanover Region was created in 2001 as a new type of urban regional body. The article deals with the conditions and goals of this administrative reform. It examines factors that contributed to the success of the reform. It is emphasised that above all the region’s predecessors’ more than three decades of experience with ...
openaire +3 more sources
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
"In this paper, we review the debate on "new regionalism," focusing on the tools used to evaluate regional trade agreements (RTAs). We find that much analysis uses tools from old trade theory in the Viner-Meade tradition, focusing on trade creation ...
Burfisher, Mary E. +2 more
core
Regional governmentality: neoliberalization and the Caribbean community single market and economy [PDF]
, 2009 Formally launched on 30 January 2006, the Caribbean Community (CARICOM) Single Market and Economy (CSME) is, like many other regional economic initiatives, designed to create an economic space in which the uninhibited flow of goods, capital and skills ...
Newstead, C
core +1 more source