Results 51 to 60 of about 32,494 (310)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Assessment of EU banking network regionalization during post-crisis period
Oeconomia Copernicana, 2018 Research background: Recent financial crisis of 2007–2008 has influenced global banking system and led to reduction of cross-border bank lending in the EU and worldwide. Global banking network has been analysed extensively in prior or post-crisis periods,
Asta Gaigaliene +2 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
, 1998 In this review, the term muscle fibre regionalization signifies the presence of regional intramuscular differences in fibre type composition. As is well known, highly regionalized muscles commonly have greater concentrations of slow fibres deep than ...
Kernell, D
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Evaluation of regionalization methods for runoff prediction in ungauged basins in Norway
, 2020 Regionalization is a common approach for runoff prediction in the basin lacking observed discharge data (called ungauged basin). Regionalization is the process of borrowing information (e.g.
Yang, Xue
core +1 more source
Journal of Interventional Epidemiology and Public HealthIntroduction: Regionalization involved devolving laboratory technical assistance, coordination, and oversight roles from the National Health Laboratory and Diagnostic Services, Ministry of Health, to regional referral hospitals, aiming to standardize ...
Anthony Kiyimba +12 more
doaj +1 more source
Regional integration and national social policies
Research & Politics, 2014 How does regionalization affect national social policies? Although there is an extensive literature on the effects of globalization on social protection, the literature on the impact of regional integration is much less developed.
Mary Anne Madeira
doaj +1 more source
Бюллетень Почвенного института им. В.В. Докучаева, 2014 Under consideration is a regionalization version corrected with the aim to renew taxons, to give a new interpretation of farming systems and to specify the qualitative and quantitative characteristics of the soil cover in agricultural areas.
D. S. Bulgakov +2 more
doaj +1 more source