Results 71 to 80 of about 82,737 (308)
Integration or regionalization: regional industrial specialization in Russia [PDF]
, 2010 The article is devoted to the trends and determinants of the transformation of Russian regions' industrial specialization during the period of economic growth. Using the methodology of statistic and econometric analysis it is tested whether the tendency
Golovanova, S.
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Delimitation of landscape units treated as estimation fields in the modelling of a landscape system
Miscellanea Geographica: Regional Studies on Development, 2013 The main objective of this paper is to represent the hierarchical structure of an environment by using two concepts: typology and regionalization. The Płock Region (1,766.95 sq. km) and transect crossing this area (796.2 sq. km) is the research location.
Richling Andrzej +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Using supervised machine learning for regional hydrological hazard estimation in metropolitan France
Journal of Hydrology: Regional StudiesStudy region: This study is carried out for 1929 gauged catchments in France, ranging from 1 to 10,000 km², where quality hydrometric observations are available for flood frequency analysis. Study focus: The regional estimation of hydrological hazards is
Qifan Ding, Patrick Arnaud
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Regional integration in Central Asia: A firm-centered view [PDF]
Regional integration remains among the main topics of international discourse in Central Asia, though the progress of international cooperation is very limited.
Libman, Alexander
core +1 more source
Reviewing its self image and redefining its role as a regional power : contemporary Japan and international population movement [PDF]
, 2010 What sort of change in policy may be possible if a state reviewed its structural conditions and the significance of its own power with regard to other actors in international relations?
Taki, Tomonori
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