Results 61 to 70 of about 32,494 (310)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2014 The goal of regionalization is multifaceted - political, developmental, economic, historical, cultural, demographic setting. From the standpoint of the European Union, the goal of regionalization is punching the border barrier between the states and the ...
Kostadinović Ivana
core +1 more source
Stem Cell Reports, 2019 Summary: The generation of brain region-specific progenitors from human embryonic stem cells (hESCs) is critical for their application. However, transcriptional regulation of neural regionalization in humans is poorly understood.
Zhuoqing Fang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A Model for the Regionalization of Higher Education: The Role and Contribution of Tuning
Tuning Journal for Higher Education, 2014 A notable evolution in the internationalization of higher education in the last decade has been the increasing emphasis on regional level collaboration and reform initiatives. The purpose of this paper is to examine the process of regionalization through
Jane Knight
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Regionalization of esophagectomy: where are we now?
, 2019 The morbidity and mortality benefits of performing high-risk operations in high-volume centers by high-volume surgeons are evident. Regionalization is a proposed strategy to leverage high-volume centers for esophagectomy to improve quality outcomes ...
Meguid, Robert +4 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
, 2018 This chapter examines current conceptual and empirical thinking about economic regionalization within the global economy, particularly in light of debates about the potential retreat of economic globalization in the second decade of the twenty-first ...
Jones, A., Andrew Jones
core +1 more source
Ecology and Evolution, 2019 Aim To date, despite their great potential biogeographical regionalization models have been mostly developed on descriptive and empirical bases. This paper aims at applying the beta‐diversity framework on a statistically representative data set to ...
Alessandro Chiarucci +8 more
doaj +1 more source