Results 61 to 70 of about 82,737 (308)
Ecology and Evolution, 2019 Aim To date, despite their great potential biogeographical regionalization models have been mostly developed on descriptive and empirical bases. This paper aims at applying the beta‐diversity framework on a statistically representative data set to ...
Alessandro Chiarucci +8 more
doaj +1 more source
Singapore's Regionalization Blueprint: The Empirics of the Case for Selective Intervention [PDF]
, 2004 Conference theme: Bridging with the Other: The Importance of Dialogue in International ...
WONG, Siang Yeung, YEOH, Caroline
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
The Regionalization Process in Brazil: influence on Policy, Structure and Organization dimensions
Revista Brasileira de Saúde Materno InfantilObjectives: to analyze the influence and performance on Policy, Structure and Organization dimensions in the regionalization process in five health regions in Brazil.
Ana Luiza d'Ávila Viana +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Sfera Politicii, 2014 Over the past five decades there have been regionalization bills in Europe, more or less successful. The representative ones for the subject in question are those elaborated in Francophile and Francophone countries such as: the Bill concerning the ...
Angela Ramona Dumitru +1 more
doaj
A Regionalization Approach Based on the Comparison of Different Clustering Techniques
Applied SciencesFor biodiversity conservation and the development of protected areas, it is essential to create strategic plans that ensure the preservation and sustainable use of natural resources.
José Luis Aguilar Colmenero +1 more
doaj +1 more source
Nationalization versus regionalization: features of the party system development in Ukraine (1991–2020) [PDF]
Annales Scientia Politica, 2022 In this article, the authors present their vision of the theoretical and empirical aspects of the party system’s nationalization and regionalization in Ukraine in 1991–2020.
Yuriy Ostapets +2 more
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