Results 61 to 70 of about 81,586 (287)

A Proposal for a Tourism Regionalization of Poland Based on the Highest Levels of Tourism in a Region [PDF]

, 2014
The paper presents a brief review of twenty proposals for tourism regionalization of either a part of or the whole of Poland (or attempts to delimit the most attractive areas in terms of leisure), formulated between 1938 and 2012.
Sobotka, Sławomir
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The Regionalization Process in Brazil: influence on Policy, Structure and Organization dimensions

Revista Brasileira de Saúde Materno Infantil
Objectives: to analyze the influence and performance on Policy, Structure and Organization dimensions in the regionalization process in five health regions in Brazil.
Ana Luiza d'Ávila Viana, Maria Paula Ferreira, Maria Alice Cutrim, Edgar Rodrigues Fusaro, Miriam Regina de Souza, Laís Mourão, Ana Paula Chancharulo de Moraes Pereira, Paulo Henrique dos Santos Mota, Fabíola Lana Iozzi, Liza Yurie Teruya Uchimura   +9 more
doaj   +1 more source

Extrapolation of regionalization equations for long-term average flow [PDF]

Engenharia Agrícola, 2016
Knowledge about long-term average flow is essential for planning and managing water resources because it represents the potential water availability. One technique used to determine streamflow is regionalization, but because most gauge stations normally ...
Fernando F. Pruski, Renata del Giudice Rodriguez, Pedro L. Pruski, Aline de A. Nunes, Fernando S. Rego   +4 more
doaj   +1 more source

Identifying hotspots and management of critical ecosystem services in rapidly urbanizing Yangtze River Delta Region, China [PDF]

, 2017
Rapid urbanization has altered many ecosystems, causing a decline in many ecosystem services, generating serious ecological crisis. To cope with these challenges, we presented a comprehensive framework comprising five core steps for identifying and ...
Cai, Wenbo, Cai, Yongli, Ferrier, Graham, Gibbs, David, Zhang, Lang   +4 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Problematic aspects and possible solutions concerning the regionalization models on the European Union

Sfera Politicii, 2014
Over the past five decades there have been regionalization bills in Europe, more or less successful. The representative ones for the subject in question are those elaborated in Francophile and Francophone countries such as: the Bill concerning the ...
Angela Ramona Dumitru, Adrian‑Cosmin Basarabă   +1 more
doaj  

A Regionalization Approach Based on the Comparison of Different Clustering Techniques

Applied Sciences
For biodiversity conservation and the development of protected areas, it is essential to create strategic plans that ensure the preservation and sustainable use of natural resources.
José Luis Aguilar Colmenero, Javier Portela Garcia-Miguel   +1 more
doaj   +1 more source