Results 141 to 150 of about 179,751 (258)

Reflexiones sobre la relacion entre ciencias sociales y actores regionales en México

open access: yesFrontera Norte, 2012
Las relaciones entre las ciencias sociales y la sociedad siempre han sido un tema polémico en México. Para algunos académicos una colaboración estrecha con los empresarios o con el gobierno puede suborninar el trabajo científico a los intereses de los ...
Alfredo HUALDE ALFARO
doaj  

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

open access: yesFEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini   +3 more
wiley   +1 more source

Gráficas 3D. Regiones tridimensionales

open access: yes, 2011
Explicación del comando RegionPlot3D de Mathematica. Este comando permite representar la intersección de 2 o más superficies en tres dimensiones.https://polimedia.upv.es/visor/?id=cbb772f5-8c11-0c41-bdd1-00fe36eac87cMoraño Fernández, JA. (2011). Gráficas
Moraño Fernández, José Antonio
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

On Stratified Regions

open access: yes, 2009
Type and effect systems are a tool to analyse statically the behaviour of programs with effects. We present a proof based on the so called reducibility candidates that a suitable stratification of the type and effect system entails the termination of the typable programs.
openaire   +3 more sources

Análisis económico-descriptivo de las regiones chilenas

open access: yes
Este trabajo proporciona un análisis económico-descriptivo de las regiones de Chile, en términos de Producto Interno Bruto Regionalizado, exportaciones y población, para el período 1985-1999.
Andrés Pardo   +2 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Evaluación integrales dobles sobre regiones determinadas

open access: yes, 2018
El vídeo describe el contenido de Evaluación integrales dobles sobre regiones determinadas, además de describir las unidades didácticas a ...
Pomalaza Romero, Orlando
core  

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