Results 151 to 160 of about 123,764 (312)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Regional patterns of industrial sector in EU countries 1980-1995. [PDF]

Industrial concentration in some regions of the European Union countries and in the central areas of EU is analysed during the period between 1980-1995.
Guisan, M.Carmen, Cancelo, M.Teresa, Diaz, M.Rosario   +2 more
core  

[Dementia and Parkinson's Disease in the rural population of western Salamanca: a cross-sectional study of prevalence and family support needs]. [PDF]

Aten Primaria
Alonso Sardón M, Montes López E, Del Álamo Gómez N, Picado Valverde EM, Yurrebaso Macho A, Martín Delgado MA.   +5 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Perspectivas del sector energético en las regiones del sur del Perú -

En la conferencia Perú Energía Sur 2024, el Dr. Arturo Vásquez, Profesor de GĚRENS, habló sobre el potencial energético de las regiones del sur de Perú.
GĚRENS
core  

Regiones naturales de Colombia

, 2017
Las Regiones Naturales de Colombia, son una increíble oportunidad de mostrar las características específicas en términos geográficos, de clima, relieve, flora y fauna de nuestro país. La idea es poder hacer que los niños y niñas que hagan las actividades
Riveros Martinez, Victor Giovanny
core  

[Epidemiology of childhood leukemia in Mexico and Latin America: Effects of vulnerability and social justice]. [PDF]

Rev Med Inst Mex Seguro Soc
Núñez-Enríquez JC, Pelayo R, Flores-Lujano J, Allende-López A, Alarcón-Ruiz E, Duarte-Rodríguez DA, Rodríguez-Muñoz AK, Rodríguez-Díaz R, Chávez-Martínez O, Mejía-Aranguré JM.   +9 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

[Dermal fillers and late-onset reactions: An emerging challenge in primary care]. [PDF]

Aten Primaria
Estalayo-Gutiérrez B, Minué-Estirado M, Mateos-Camino L, Rodríguez-Tadeo G.   +3 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source