Results 151 to 160 of about 817,122 (295)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

¿Cómo las regiones influyen en el proceso decisorio comunitario? Mecanismos de activación ascendente de las entidades sub-estatales europeas

Revista UNISCI, 2008
Que la Unión Europea es actualmente una organización supranacional dirigida por los estados que la forman es una obviedad. Sin embargo, no es menos cierto que muchas de las regiones que integran esos estados llevan un cuarto de siglo intentando influir ...
Jorge Tuñón
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

[Study of Successful Emotional Memory Encoding with Functional Magnetic Resonance Imaging: A Meta-Analysis Comparing the Affective Salience of Words Versus Images]. [PDF]

Rev Neurol
Kotkowski Baca E, García Velázquez SA, Fox Selby PT.   +2 more
europepmc   +1 more source

¿Qué hay detrás de las diferencias en la desigualdad entre los países? [PDF]

(Disponible en idioma inglés únicamente) En este trabajo se presentan técnicas de simulación microeconómica para analizar qué es lo que hay detrás de las diferencias en la desigualdad de un país a otro.
Marianne Hilgert, Miguel Székely
core  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

[Epidemiology of childhood leukemia in Mexico and Latin America: Effects of vulnerability and social justice]. [PDF]

Rev Med Inst Mex Seguro Soc
Núñez-Enríquez JC, Pelayo R, Flores-Lujano J, Allende-López A, Alarcón-Ruiz E, Duarte-Rodríguez DA, Rodríguez-Muñoz AK, Rodríguez-Díaz R, Chávez-Martínez O, Mejía-Aranguré JM.   +9 more
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Trends and spatial distribution of precarious work conditions for nurses in Brazil based on the type of employment bond. [PDF]

Rev Lat Am Enfermagem
Aquino ÉC, Guimarães RA, Pagotto DDP, Duarte JA, Silva Filho AID, Borges Júnior CV.   +5 more
europepmc   +1 more source