Results 101 to 110 of about 3,554,144 (293)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Deregressing estimated breeding values and weighting information for genomic regression analyses

Genetics Selection Evolution, 2009
Background Genomic prediction of breeding values involves a so-called training analysis that predicts the influence of small genomic regions by regression of observed information on marker genotypes for a given population of individuals.
Taylor Jeremy F, Garrick Dorian J, Fernando Rohan L   +2 more
doaj   +1 more source

HYBRID INTERREGIONAL INPUT-OUTPUT CONSTRUCTION METHODS: APPLIED TO THE SEVEN REGION SPANISH INPUT-OUTPUT TABLE [PDF]

This paper searches for an optimal combination of non-survey methods when constructing a Spanish interregional input-output table for the region of Madrid and the five provinces of the region of Castilla-La Mancha (CLM), given thirteen Spanish regional ...
Fernando Escobedo-Cardeñoso, Jan Oosterhaven   +1 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A robust quantification of H2O in silicate glasses through micro-Raman spectroscopy: insights on the compositional effect

Volcanica
Micro-Raman spectroscopy is considered one of the most promising, rapid and economical methods to measure the water content in small volumes (a few μm3) of natural glasses (e.g.
Filippo Ridolfi, Diego González-García
doaj   +1 more source

Regression Analyses of Distributions using Quantile Functional Regression

, 2018
Radiomics involves the study of tumor images to identify quantitative markers explaining cancer heterogeneity. The predominant approach is to extract hundreds to thousands of image features, including histogram features comprised of summaries of the marginal distribution of pixel intensities, which leads to multiple testing problems and can miss out on
Yang, Hojin, Baladandayuthapani, Veerabhadran, Rao, Arvind U. K., Morris, Jeffrey S.   +3 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Pain-induced sleep disturbances fully mediate the association between symptomatic hip and knee osteoarthritis and poor sleep quality: a cross-sectional study

Bone & Joint Open
Aims: We assessed whether symptomatic end-stage hip and knee osteoarthritis (OA) are associated with poorer sleep quality and to what extent pain mediates these associations.
Juliette C. Sorel, Bowien H. W. Korterink, Raymond Noordam, Frits R. Rosendaal, Magreet Kloppenburg, Rob G. H. H. Nelissen, Saskia le Cessie, Rudolf W. Poolman, Birit F. P. Broekman, Maaike G. J. Gademan, On behalf of the LOAS and NEO study group   +10 more
doaj   +1 more source

An Ordinal Regression Model using Dealer Satisfaction Data [PDF]

This article analyses dealer satisfaction data in the agricultural technology market in Germany. The dealers could rate their suppliers in the 'overall satisfaction' and in 38 questions which can be summarized in 8 dimensions. An ordinal regression model
Alexander Staus
core