Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Predicted risk factors associated with secondary infertility in women: univariate and multivariate logistic regression analyses. [PDF]
Front Med (Lausanne), 2023 Fatima W +4 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Different channels of impact of education on poverty: an analysis for Colombia [PDF]
This paper analyses pecuniary and non-pecuniary effects of education on poverty. Two are the main contributions: first, the pecuniary analysis employs the recently developed technique of instrumental variable quantile regression, very helpful method when
Blanca Zuluaga
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
The regression trap: why regression analyses are not suitable for selecting determinants to target in behavior change interventions. [PDF]
Health Psychol Behav Med, 2023 Crutzen R, Peters GY.
europepmc +1 more source
CONTRIBUTIONS OF NONALCOHOLIC BEVERAGES TO THE U.S. DIET [PDF]
This report analyzes consumer demand and nutritional issues associated with nonalcoholic beverages purchased for at-home use by looking at demographic variables such as household size, household income, education level, and region.
Capps, Oral, Jr. +4 more
core +1 more source
USE OF THE SIMPLE LINEAR REGRESSION MODEL IN MACRO-ECONOMICAL ANALYSES [PDF]
Revista Română de Statistică, 2011 The article presents the fundamental aspects of the linear regression, as a toolbox which can be used in macroeconomic analyses. The article describes the estimation of the parameters, the statistical tests used, the homoscesasticity and ...
Constantin ANGHELACHE
doaj
The marginality principle revisited: Should "higher-order" terms always be accompanied by "lower-order" terms in regression analyses? [PDF]
Biom J, 2023 Morris TP, van Smeden M, Pham TM.
europepmc +1 more source