Results 91 to 100 of about 6,113,629 (258)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Bayesian Analysis for Penalized Spline Regression Using WinBUGS [PDF]
Penalized splines can be viewed as BLUPs in a mixed model framework, which allows the use of mixed model software for smoothing. Thus, software originally developed for Bayesian analysis of mixed models can be used for penalized spline regression ...
Ciprian M. Crainiceanu +2 more
core +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Electronic Journal of Plant BreedingOat holds significant importance in global agriculture and nutrition due to their adaptability and versatility. In the present study, Principal Component Analysis (PCA) and Regression analysis were carried out to identify the cause and effect ...
Rukoo Chawla1&2, Minakshi Jattan1, D.S. Phogat3, Babita Rani4, Deepankar Verma5, Naresh*1 and Prachi Mahla2
doaj +1 more source
IMPLICATIONS OF FISCAL STIMULI IN MACROECONOMIC PLANE AT THE LEVEL OF SOME DEVELOPED AND EMERGING COUNTRIES [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2018 Determining an optimal tax system is one of the main goals of fiscal policy applied in countries looking for sustainable economic development. Acknowledging that tax deductions affect a country's entire economic activity, in the research carried out ...
VODĂ ALINA DANIELA, DOBROTĂ GABRIELA
doaj
Innovation and market value: a quantile regression analysis [PDF]
We construct a new database by matching firm-level Compustat data to NBER patent data, for four 2-digit complex technology sectors. Whilst conventional regression estimators show that the stock market does recognise efforts at innovation, quantile ...
Alex Coad, Rekha Rao
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Generalization of regression analysis to the spatial context [PDF]
Our day-to-day experience suggests that certain variables are local in their effects. The influence of such variables is limited within the boundaries of the spatial entity (district) where they are physically located.
Mishra, SK
core +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source