Results 81 to 90 of about 2,496,534 (248)

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

open access: yesFEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado   +4 more
wiley   +1 more source

Identification of amino acids essential for angulin‐1/3 binding of the tricellular tight junction binder, angubindin‐1

open access: yesFEBS Open Bio, EarlyView.
Angubindin‐1 binds angulin‐1/‐3 at tricellular tight junctions, enhancing intestinal macromolecule permeation. Alanine scanning identified six essential residues (L562, L598, E638, V640, Y643, and K644) of angubindin‐1 critical for binding to angulin‐1/‐3 and permeation‐enhancing activity, providing insights for the development of targeted noninvasive ...
Taiki Kuzu   +8 more
wiley   +1 more source

Data-Driven and Machine-Learning-Based Real-Time Viscosity Measurement Using a Compliant Mechanism

open access: yesApplied Sciences
In this work, a novel method of viscosity measurement is proposed using a device comprising a compliant mechanism, a vibration source, and a piezoelectric sensor.
Nitin V. Satpute   +8 more
doaj   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

open access: yesFEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel   +9 more
wiley   +1 more source

Predictive modelling of sustainable concrete compressive strength using advanced machine learning algorithms

open access: yesAdvances in Civil and Architectural Engineering
Considerable efforts have been made to increase the compressive strength of concrete by incorporating industrial by-products such as recycled aggregates and manufactured sand as partial substitutes for natural materials.
Tejas Joshi   +3 more
doaj   +1 more source

Pediatric glioma and medulloblastoma risk and population demographics: a Poisson regression analysis [PDF]

open access: gold, 2020
Ivo S. Muskens   +7 more
openalex   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

Impact of the Significant Financial Potential Factors on the Economic Development of the Region

open access: yesInternational Journal of Technology
Financial potential is an important indicator that reflects the availability of resources and opportunities for the development of a region. A comprehensive study of this indicator is very necessary to achieve growth and improve the financial and ...
Anastasiya Koshevarova   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy