Results 41 to 50 of about 3,861,847 (314)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
ENGINEERING METHOD OF MODELING AND OPTIMIZATION OF CHEMICAL-TECHNOLOGICAL PROCESSES
Российский технологический журнал, 2017 In the proposed work, the engineering method of modeling and optimization will be described using the example of tire development and rubber products.
I. V. Veselov, Y. A. Gamlitskiy
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Vibrating roller with compacted soil interaction modelling
Вестник СибАДИIntroduction. Vibrating rollers are the most common means of compacting soils in construction. The nature of stress development on the contact surface of the roller with the ground depends on the technical characteristics of the vibrating roller (the ...
I. S. Tyuremnov, D. A. Shorohov
doaj +1 more source
Medičnì Perspektivi, 2019 This work is the first part of our study to develop alternative experimental mathematic models for predicting toxicity of insecticides. In the first stage, calculations will be carried out and the most reliable models will be proposed.
A. M. Antonenko +3 more
doaj +1 more source
On generalised estimating equations for vector regression [PDF]
Australian & New Zealand Journal of Statistics, 2017 Generalized estimating equations (GEE; Liang & Zeger 1986) for general vector regression settings are examined. When the response vectors are of mixed type (e.g. continuous-binary response pairs), the GEE approach is a semiparametric alternative to full-likelihood copula methods, and is closely related to the mean-covariance estimation equations ...
openaire +5 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Credibility analysis of the regression equations.
, 2014 Credibility analysis of the regression equations.
Jinquan Yue (668362) +5 more
core +1 more source