Results 101 to 110 of about 2,028,100 (318)
Bias of Maximum-Likelihood estimates in logistic and Cox regression models: A comparative simulation study [PDF]
, 2003 Parameter estimates of logistic and Cox regression models are biased for finite samples. In a simulation study we investigated for both models the behaviour of the bias in relation to sample size and further parameters.
Lenz-Tönjes, Rebecca +7 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Features of 14-15 years’ age boys’ training to physical exercises
Pedagogics, Psychology, Medical-Biological Problems of Physical Training and Sports, 2015 Purpose: to optimize modes of 14-15 years’ age boys’ training to physical exercises in educational process. Material: in experiment 14 years’ age boys (n=24) and 15 years’ old boys (n=24) participated. Plan of factorial experiment was used.
O.O. Kapkan
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Bootstrap Tests of Nonnested Linear Regression Models [PDF]
The J test for nonnested regression models often works badly as an asymptotic test, but it generally works very well when bootstrapped. We provide a theoretical analysis of the J test which explains both of these phenomena.
Russell Davidson, James G. MacKinnon
core
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Reparameterized Scale Mixture of Rayleigh Distribution Regression Models with Varying Precision
MathematicsIn this paper, we introduce a new parameterization for the scale mixture of the Rayleigh distribution, which uses a mean linear regression model indexed by mean and precision parameters to model asymmetric positive real data. To test the goodness of fit,
Pilar A. Rivera +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie ŚrodowiskaSince entering the market in 2009, Bitcoin has had a price that is extremely erratic. Its price is influenced by factors such as adoption rates, regulatory changes, geopolitical occurrences, and macroeconomic developments. Experts believe that Bitcoin's
Mamun Ahmed +3 more
doaj +1 more source