Results 141 to 150 of about 1,720,913 (319)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Contrasting Global and Patient-Specific Regression Models via a Neural Network Representation. [PDF]

Biom J
Behrens M, Stolz D, Papakonstantinou E, Nolde JM, Bellerino G, Rohde A, Hess M, Binder H.   +7 more
europepmc   +1 more source

Using Laplace Regression to Model and Predict Percentiles of Age at Death When Age Is the Primary Time Scale [PDF]

, 2015
Andrea Bellavia, Andrea Discacciati, Matteo Bottai, Alicja Wolk, Nicola Orsini   +4 more
openalex   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Improving genomic prediction in wheat with random regression models with genotype-specific phenology-driven environmental covariates. [PDF]

Plant Genome
Dhakal R, Sniadower G, Silva P, Lado B, Sandro P, Rebollo I, Quincke M, Dawson JC, Gutiérrez L, González Barrios P.   +9 more
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Adversarial Attention Modeling for Multi-dimensional Emotion Regression [PDF]

, 2019
Suyang Zhu, Shoushan Li, Guodong Zhou
openalex   +1 more source

Variable Selection for Nonlinear Cox Regression Model via Deep Learning

, 2022
Kexuan Li
openalex   +2 more sources

Using a Random Coefficient Regression Model to Jointly Determine the Optimal Critical Level and Lot Sizing [PDF]

, 2020
Xuejuan Liu, Fei Zhao
openalex   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source