Results 161 to 170 of about 1,720,913 (319)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Charting the Landscape of Oxygen Ion Conductors: A 60-Year Dataset with Interpretable Regression Models. [PDF]

Sci Data
Jang SH, Kiyohara S, Takamura H, Kumagai Y.   +3 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Change Point Detection in Panel Linear Regression Models Based on Jump Information Criterion. [PDF]

Entropy (Basel)
Zhao W, Fan L, Xia Z.
europepmc   +1 more source

Pembuatan Model Pemeringkatan Ulasan Menggunakan Metode Random Forest Regression

, 2021
Nisrina Fadhilah Fano
openalex   +2 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Are machine learning models superior to logistic regression models to predict 30-day mortality post-hip fracture surgery? [PDF]

JBMR Plus
Issa Z, Trad F, Yammine R, Rhayem C, Ghosn A, Alwan J, Tamim H, Haidar R, Chehab A, El-Hajj Fuleihan G.   +9 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Regularized regression models for accurate prediction of HIV progression in ART patients: a comparative study. [PDF]

Sci Rep
Owoade GO, Okewole DM, Nziku CK, Lukman AF.   +3 more
europepmc   +1 more source

Dynamic Modeling of Photovoltaic-Thermal Systems Using Polynomial Regression

Kamran Moradi, Fereshteh Jafari, Fariba Moghaddam, Qobad Shafiee   +3 more
openalex   +1 more source