Results 51 to 60 of about 1,745,236 (282)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Parallel Recurrent Module With Inter-Layer Attention for Capturing Long-Range Feature Relationships

IEEE Access, 2022
Capturing long-range feature relationships is becoming a central issue with regard to convolutional neural networks (CNNs). In particular, several recent end-to-end trainable attention modules have attempted to model spatial-channel relationships within ...
Eunseok Kim, Jihwan Bae, Inwook Shim
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Multi-granularity Traffic Detection System of Group Based Policy for SDN [PDF]

Jisuanji gongcheng, 2017
In order to improve the network control ability and security,researchers usually utilize the features of centralized control and flow table control of Software Defined Network(SDN) to develop a lot of security applications.However,those security ...
DU Ruiying,HU Li,CHEN Jing,CHEN Jiong
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Annsemimaximal and Coannsemimaximal Modules

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
        Some authors studied modules with annihilator of every nonzero submodule is prime, primary or maximal. In this paper, we introduce and study annsemimaximal and coannsemimaximal modules, where an R-module M is called annsemimaximal (resp ...
I. M.A. Hadi, , H. Y. Khalaf
doaj  

FPGA-based network intrusion detection for IEC 61850-based industrial network

ICT Express, 2018
This paper proposes an FPGA-based network intrusion detection system for the IEC 61850-based industrial network that is specially designed for substation automation. The proposed system uses the Shift-And algorithm for detecting malicious network packets
Junsik Kim, Jaehyun Park
doaj   +1 more source

A note on a generalization of injective modules

Karpatsʹkì Matematičnì Publìkacìï, 2020
As a proper generalization of injective modules in term of supplements, we say that a module $M$ has the property (ME) if, whenever $M\subseteq N$, $M$ has a supplement $K$ in $N$, where $K$ has a mutual supplement in $N$. In this study, we obtain that $(
B.N. Türkmen, E. Türkmen
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source