Results 61 to 70 of about 1,745,236 (282)
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Simple modules over Auslander regular rings
Open Mathematics, 2017 In this paper, we discuss the properties of simple modules over Auslander regular rings with global dimension at most 3. Using grade theory, we show the right projective dimension of ExtΛ1(S,Λ)$\begin{array}{} \text{Ext}_{{\it\Lambda}}^{1}(S,\ {\it ...
Huang Chonghui, Zheng Lijing
doaj +1 more source
Interactive E-module Based on H-Guided Inquiry: Optimize the ICT Skills and Learning Achievements
Berkala Ilmiah Pendidikan Fisika, 2020 This study aimed to optimize the ICT skills and the learning achievement of the students on the subject of the regular circular motion through the development of the interactive e-module that is based on the Hybrid Guided Inquiry with good criteria. As a
Nur Rohmah Utami +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A note on regular modules [PDF]
Bulletin of the Australian Mathematical Society, 1974 Kaplansky's observation, namely, a commutative ring R is (von Neumann) regular if and only if each simple R-module is injective, is generalized to projective modules over a commutative ring.
openaire +2 more sources
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Red Guide Paper 42: Managing a Module Part 1: Delivering a Module [PDF]
, 2008 This revised guide covers various aspects of the process for developing a new module and provides an overview of the general principles of module ...
Smailes, Joanne +2 more
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source