Results 81 to 90 of about 89,950 (257)

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Rings Whose Pure-Projective Modules Have Maximal or Minimal Projectivity Domain

Journal of New Theory
In this study, we investigate the projectivity domain of pure-projective modules. A pure-projective module is called special-pure-projective (s-pure-projective) module if its projectivity domain contains only regular modules. First, we describe all rings
Zübeyir Türkoğlu
doaj   +1 more source

Regularity of 𝐅𝐈-modules and local cohomology

Proceedings of the American Mathematical Society, 2018
We resolve a conjecture of Ramos and Li that relates the regularity of an F I \mathbf {FI}
Nagpal, Rohit, Sam, Steven V, Snowden, Andrew   +2 more
openaire   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Preparing Chinese higher vocational students to succeed in a globalized and multicultural world: Enhancing their oral English competence and intercultural competence

Acta Psychologica
In response to pedagogical reforms in English language teaching (ELT) within Chinese higher vocational education, growing attention has been placed on cultivating students' professional oral English competence alongside intercultural communicative ...
Shulin Yu, Bee Eng Wong
doaj   +1 more source

Entre cadrage institutionnel et bricolages individuels. Devenir ou pas animateur de module « Projet Personnel et Professionnel » en IUT

Cahiers de la Recherche sur l'Education et les Savoirs, 2018
Since 2005 a module called “Personal and vocational project” (PPP) has appeared in the IUT, a vocational training in higher education. For most of teachers and academics working in these IUTs in France (around 10.000, divided into 115 institutes) it ...
Stéphanie Tralongo
doaj   +1 more source

The direct sum order in regular modules

Journal of Algebra and Its Applications, 2019
In this paper, we define the direct sum relation on a module and prove that this is a partial order when the module is regular. We also focus on a regular support and a strong regular support of an element in a module, which are extensions of a generalized inverse and a reflexive generalized inverse of an element in a ring, respectively. Using regular
Ungor, Burcu, Halicioglu, Sait, Harmanci, Abdullah   +2 more
openaire   +3 more sources