Results 71 to 80 of about 394,267 (278)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Non-commutative Regular Rings

Journal of Algebra, 2001
In a previous article, the author introduced a noncommutative concept of Cohen-Macaulay ring based on invertible ideals rather than invertible elements [J. Algebra 236, No. 2, 522-548 (2001; Zbl 0982.16008)]; here he narrows the focus to a corresponding notion of regular (semi)local ring.
openaire   +1 more source

Flat Regular Quotient Rings [PDF]

Transactions of the American Mathematical Society, 1969
0. Introduction and notation. In this paper we study the condition that the maximal right quotient (MRQ) ring Q [10, p. 106] of a right nonsingular ring R with 1 is flat as a left R-module. It is known [11, p. 134] that if Q is the classical right quotient ring of R, then Q is flat as a left R-module. This is not always the case with the MRQ ring of R:
openaire   +2 more sources

GENERALIZING $\pi$-REGULAR RINGS

Taiwanese Journal of Mathematics, 2015
to appear in Taiwanese J ...
Danchev, Peter, Šter, Janez
openaire   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

On Almost Weakly np – injective Rings [PDF]

Al-Rafidain Journal of Computer Sciences and Mathematics, 2018
The ring R is called right almost weakly np –injective, if for any , there exists a positive integer n and a left ideal  of R such that . In this paper, we give some characterization and properties of almost weakly np – injective rings.
Raida Mahmood, Amaar Ghaze
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

On Strongly - Regular Rings

مجلة ابحاث كلية التربية الاساسية
             In our study we examine  definition of strongly γ -regular rings and associates, investigate  interplay between strongly γ - regular rings and other reduced rings. We also study GP – injective modules, and discuss its relation with strongly
Luma Ahmed Khaleel, Beyda S. Abdullah
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source