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Regulating the Regulators [PDF]
Science, 2003 Activation of the immune system in response to pathogens carries with it the possibility of a harmful autoimmune response. In their Perspective, Powrie and Maloy discuss a newly recognized group of regulatory T cells (T) that fine tune protective antimicrobial immune responses in order to minimize harmful immune pathology ( Hori et ...
Powrie, F, Maloy, K
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Biological Research, 2023 Background Despite representing the largest fraction of animal life, the number of insect species whose genome has been sequenced is barely in the hundreds.
Sanae Kobayashi +32 more
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Canadian Respiratory Journal, 2022 Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible, and progressive interstitial lung disease characterized by recurrent alveolar epithelial cell injury, fibroblast hyperproliferation, and cumulative deposition of extracellular matrix leading
Lan Wang +7 more
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Uncovering deeply conserved motif combinations in rapidly evolving noncoding sequences
Genome Biology, 2021 Background Animal genomes contain thousands of long noncoding RNA (lncRNA) genes, a growing subset of which are thought to be functionally important. This functionality is often mediated by short sequence elements scattered throughout the RNA sequence ...
Caroline Jane Ross +5 more
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BMC Medical Informatics and Decision Making, 2022 Background Smartphone technology can support paperless reporting of adverse drug reactions (ADRs). The aims of this study were to systematically assess smartphone ADR-reporting applications, understand their qualitative and quantitative impact on ADR ...
Ayako Fukushima +3 more
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GqPCR-stimulated dephosphorylation of AKT is induced by an IGBP1-mediated PP2A switch
Cell Communication and Signaling, 2022 Background G protein-coupled receptors (GPCRs) usually regulate cellular processes via activation of intracellular signaling pathways. However, we have previously shown that in several cell lines, GqPCRs induce immediate inactivation of the AKT pathway ...
Guy Nadel +9 more
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The Internet: To Regulate or Not Regulate? [PDF]
SSRN Electronic Journal, 2018 This submission was prepared in response to a call for evidence launched on 29 March 2018 by the House of Lords Select Committee on Communications entitled “The Internet: To Regulate or Not to Regulate?”. The broad inquiry sought evidence to explore how the regulation of the internet should be improved, and to consider whether online platforms which ...
Rachel Allsopp +5 more
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BMJ, 2002 The British government has plans for a new council to oversee the eight statutory regulators of health professionals (see box). The plans went out for consultation in the summer1 and are included in a bill currently before parliament.2 Proposals for the new overarching council were mooted in the NHS plan and backed by the recent Kennedy report into ...
Belinda Finlayson, Steve Dewar
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BMC Plant Biology, 2022 Background Abscisic acid receptors (ABR) involve transduction of the ABA signaling in plants, impacting largely on stress-defensive physiological processes and plant osmotic stress response. In this study, we characterized TaPYL4, a gene of ABR family in
Yanyang Zhang +6 more
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PLK1 Signaling in Breast Cancer Cells Cooperates with Estrogen Receptor-Dependent Gene Transcription
Cell Reports, 2013 Polo-like kinase 1 (PLK1) is a key regulator of cell division and is overexpressed in many types of human cancers. Compared to its well-characterized role in mitosis, little is known about PLK1 functions in interphase.
Michael Wierer +6 more
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