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Ribonucleotide reductase: regulation, regulation, regulation

Trends in Biochemical Sciences, 1992
Ribonucleotide reductase (RNR) catalyses the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. It is composed of two dissimilar subunits, R1, the large subunit containing the allosteric regulatory sites, and R2, the small subunit containing a binuclear iron center and a tyrosyl free radical.
S J, Elledge, Z, Zhou, J B, Allen
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Regulating the regulators

Science, 2017
Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
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Regulating 'Unnecessary Surgery' Regulations

Archives of Ophthalmology, 1978
To the Editor. —Dr Wong's special communication entitled, "Indications for Cataract Surgery: Psycholinguistic Considerations," which appeared in the MarchArchives(96:526-528, 1978), superbly states the problems facing both patient and surgeon in the often-difficult process of deciding the point at which to intervene surgically in a patient with ...
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