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Ribonucleotide reductase: regulation, regulation, regulation
Trends in Biochemical Sciences, 1992Ribonucleotide reductase (RNR) catalyses the rate limiting step in the production of deoxyribonucleotides needed for DNA synthesis. It is composed of two dissimilar subunits, R1, the large subunit containing the allosteric regulatory sites, and R2, the small subunit containing a binuclear iron center and a tyrosyl free radical.
S J, Elledge, Z, Zhou, J B, Allen
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Science, 2017
Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
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Autoimmunity Inhibitory receptors on T cells, including LAG3 (encoded by lymphocyte-activation gene 3 ), limit immune-mediated damage to the host. LAG3 is expressed by exhausted conventional T cells in the tumor microenvironment. The role of LAG3 in regulatory T cells (Tregs) has remained unclear.
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Science's STKE, 2006
MicroRNAs (miRNAs) have emerged as posttranscriptional regulators of gene expression that appear to have important roles in complex processes like development and the development of cancer. Although the abundance of miRNAs increases dramatically during development and is decreased in some cancer cells, how the production of miRNAs is ...
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MicroRNAs (miRNAs) have emerged as posttranscriptional regulators of gene expression that appear to have important roles in complex processes like development and the development of cancer. Although the abundance of miRNAs increases dramatically during development and is decreased in some cancer cells, how the production of miRNAs is ...
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Science, 1999
Major histocompatibility complex (MHC) class II antigens are almost exclusively expressed on immune cells such as dendritic cells and activated macrophages. It is known that their expression is necessary for the activation of lymphocytes and for a healthy immune response.
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Major histocompatibility complex (MHC) class II antigens are almost exclusively expressed on immune cells such as dendritic cells and activated macrophages. It is known that their expression is necessary for the activation of lymphocytes and for a healthy immune response.
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To Regulate or Not to Regulate?
1975There.is a growing clamor: for railroad deregulation. The arguments suggest competition will work, regulation is costly and a failure. Only the naive could believe two or three firms provide effective competition. Vested interests have kept regulations from working. Such political and economic power would keep competition from working. Heavy dependence
Wills, Walter J., Wills, Walter J.
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Science, 2007
Growth factors and nutrients, particularly amino acids, regulate cell growth and proliferation in part through the serine-threonine protein kinase mTOR (mammalian target of rapamycin). Activity of mTOR is regulated through the small guanosine triphosphatase Rheb (Ras homolog enriched in brain). Bai et al .
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Growth factors and nutrients, particularly amino acids, regulate cell growth and proliferation in part through the serine-threonine protein kinase mTOR (mammalian target of rapamycin). Activity of mTOR is regulated through the small guanosine triphosphatase Rheb (Ras homolog enriched in brain). Bai et al .
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