Results 21 to 30 of about 2,593,342 (293)
Cell Reports, 2014 The Wnt/β-catenin pathway and Nanog are key regulators of embryonic stem cell (ESC) pluripotency and the reprogramming of somatic cells. Here, we demonstrate that the repression of Dkk1 by Nanog, which leads indirectly to β-catenin activation, is ...
Lucia Marucci +5 more
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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence
Nature Communications, 2020 Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence.
Bo Zhao +11 more
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Infrared regulators and SCETII [PDF]
Phys.Rev. D69 (2004) 114011, 2003 We consider matching from SCETI, which includes ultrasoft and collinear particles, onto SCETII with soft and collinear particles at one loop. Keeping the external fermions off their mass shell does not regulate all IR divergences in both theories. We give a new prescription to regulate infrared divergences in SCET.
arxiv +1 more source
The regulators and the regulated [PDF]
Chemical & Engineering News Archive, 1983 It is far too early to make any final assessment of what has been happening at the Environmental Protection Agency these past few weeks. The resignation of Administrator Anne Burford and the firing of other senior agency officials are only the outward manifestations of the bigger issue of this Administration's attitude toward the environment.
openaire +2 more sources
Intravital imaging of hair-cell development and regeneration in the zebrafish
Frontiers in Neuroanatomy, 2013 Direct videomicroscopic visualization of organ formation and regeneration in toto is a powerful strategy to study cellular processes that often cannot be replicated in vitro.
Hernan eLopez-Schier +5 more
doaj +1 more source
A subset of conserved mammalian long non-coding RNAs are fossils of ancestral protein-coding genes
Genome Biology, 2017 Background Only a small portion of human long non-coding RNAs (lncRNAs) appear to be conserved outside of mammals, but the events underlying the birth of new lncRNAs in mammals remain largely unknown.
Hadas Hezroni +5 more
doaj +1 more source
Journal of Oral Microbiology, 2021 Introduction: Cystic fibrosis (CF) is an autosomal genetic disease, associated with the production of excessively thick mucosa and with life-threatening chronic lung infections. The microbiota of the oral cavity can act as a reservoir or as a barrier for
Jesse R. Willis +15 more
doaj +1 more source
Regulatory Markets: The Future of AI Governance [PDF]
arXiv, 2023 Appropriately regulating artificial intelligence is an increasingly urgent policy challenge. Legislatures and regulators lack the specialized knowledge required to best translate public demands into legal requirements. Overreliance on industry self-regulation fails to hold producers and users of AI systems accountable to democratic demands.
arxiv
Regulating the Regulators: microRNA and Asthma [PDF]
World Allergy Organization Journal, 2011 One obstacle to developing an effective therapeutic strategy to treat or prevent asthma is that the fundamental causes of asthma are not totally understood. Asthma is thought to be a chronic TH2 immune-mediated inflammatory disease. Epigenetic changes are recognized to play a role in the initiation and maintenance of a TH2 response.
Shyam S. Mohapatra +5 more
openaire +3 more sources
Phenotyping Diabetes Mellitus on Aggregated Electronic Health Records from Disparate Health Systems
Pharmacoepidemiology, 2023 Background: Identifying patients with diabetes mellitus (DM) is often performed in epidemiological studies using electronic health records (EHR), but currently available algorithms have features that limit their generalizability.
Hui Xing Tan +15 more
doaj +1 more source