Results 141 to 150 of about 1,659,012 (319)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Complex genetic and epigenetic regulation deviates gene expression from a unifying global transcriptional program

, 2019
Mónica Chagoyen, Juan F. Poyatos
openalex   +2 more sources

Epigenetic regulation of quiescent herpes simplex virus type 1 gene expression [PDF]

, 2010
Michael W. Ferenczy
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

microRNA-dependent regulation of gene expression in GABAergic interneurons. [PDF]

Front Cell Neurosci, 2023
Kołosowska KA, Schratt G, Winterer J.
europepmc   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Epigenetic Regulation and Gene Expression Profiles in Cervical Swabs: Toward Non-Invasive Biomarkers of Cervical Lesion Progression. [PDF]

Epigenomes
Kašubová I, Hornáková A, Kotúľová L, Rokos T, Kolková Z, Kapinová A, Pribulová T, Kozubík E, Kalman M, Biringer K, Kúdela E, Holubeková V.   +11 more
europepmc   +1 more source

Frog Chromogranin A Messenger Ribonucleic Acid Encodes Three Highly Conserved Peptides. Coordinate Regulation of Proopiomelanocortin and Chromogranin A Gene Expression in the Pars Intermedia of the Pituitary During Background Color Adaptation1 [PDF]

, 1999
Valérie Turquier, Hubert Vaudry, Sylvie Jégou, Youssef Anouar   +3 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Regulation of mucin gene expression in human nasal mucosa

, 2007
Joo‐Heon Yoon
openalex   +2 more sources