Results 241 to 250 of about 1,906,383 (319)

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

Molecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source

Two levels of regulation of beta-interferon gene expression in human cells.

, 1983
Nitin Raj, Paula M. Pitha
openalex   +1 more source

GLIS3 expression in the thyroid gland in relation to TSH signaling and regulation of gene expression. [PDF]

Cell Mol Life Sci
Kang HS, Grimm SA, Liao XH, Jetten AM.
europepmc   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

The Tissue-specific Expression and Developmental Regulation of Two Nuclear Genes Encoding Rat Mitochondrial Proteins

, 1989
Daniel P. Kelly, Jeffrey I. Gordon, R Alpers, Arnold W. Strauss   +3 more
openalex   +1 more source

Role of lncRNAs related to NRs in the regulation of gene expression

Pierouli K, Papageorgiou L, Chrousos GP, Eliopoulos E, Vlachakis D.   +4 more
europepmc   +1 more source

Representation of non-coding RNA-mediated regulation of gene expression using the Gene Ontology. [PDF]

RNA Biol
Antonazzo G, Gaudet P, Lovering RC, Attrill H.   +3 more
europepmc   +1 more source

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas.

Gastroenterology, 1994
C. Eberhart, R. Coffey, A. Radhika, F. Giardiello, S. Ferrenbach, R. Dubois   +5 more
semanticscholar   +1 more source