Results 231 to 240 of about 183,339 (262)

Molecular mechanisms of PI4K regulation and their involvement in viral replication

Traffic, 2022
AbstractLipid phosphoinositides are master signaling molecules in eukaryotic cells and key markers of organelle identity. Because of these important roles, the kinases and phosphatases that generate phosphoinositides must be tightly regulated. Viruses can manipulate this regulation, with the Type III phosphatidylinositol 4‐kinases (PI4KA and PI4KB ...
Jacob A. McPhail, John E. Burke
openaire   +2 more sources

Ebola virus replication is regulated by the phosphorylation of viral protein VP35

Biochemical and Biophysical Research Communications, 2020
Ebola virus (EBOV) is a zoonotic pathogen, the infection often results in severe, potentially fatal, systematic disease in human and nonhuman primates. VP35, an essential viral RNA-dependent RNA polymerase cofactor, is indispensable for Ebola viral replication and host innate immune escape.
Lin, Zhu, Ting, Gao, Weihong, Yang, Yaoning, Liu, Xuan, Liu, Yong, Hu, Yanwen, Jin, Ping, Li, Ke, Xu, Gang, Zou, Lei, Zhao, Ruiyuan, Cao, Wu, Zhong, Xianzhu, Xia, Cheng, Cao   +14 more
openaire   +2 more sources

Biomolecular Condensation of the Human Papillomavirus E2 Master Regulator with P53: Implications in Viral Replication

SSRN Electronic Journal, 2022
p53 exerts its tumour suppressor activity by modulating hundreds of genes and it can also repress viral replication. Such is the case of human papillomavirus (HPV) through targeting the E2 master regulator, but the biochemical mechanism is not known.
Borkosky, Silvia Susana, Fassolari, Marisol, Campos León, Karen, Rossi, Andrés Hugo, Salgueiro, Mariano, Pascuale, Carla Antonela, Martínez, Ramón Peralta, Gaston, Kevin, de Prat Gay, Gonzalo   +8 more
openaire   +3 more sources

HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication

Nature Medicine, 2004
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) persists despite a vigorous virus-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% of infected individuals. Here we report that HTLV-1 has evolved a genetic function to restrict its own replication by a novel post-transcriptional mechanism.
Christophe, Nicot, Miroslav, Dundr, Julie M, Johnson, Jake R, Fullen, Norma, Alonzo, Risaku, Fukumoto, Gerald L, Princler, David, Derse, Tom, Misteli, Genoveffa, Franchini   +9 more
openaire   +2 more sources

Cytokine regulation of lactate dehydrogenase-elevating virus: inhibition of viral replication by interferon-γ

Antiviral Research, 1994
The mechanisms which regulate the replication of lactate dehydrogenase-elevating virus (LDV), a persistent murine model virus which infects macrophages, are unclear. For this study, the effects of murine recombinant interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) on LDV replication were examined.
W A, Cafruny, S E, Bradley, J J, Broen, G H, Wong   +3 more
openaire   +2 more sources

Regulation of apoptosis and replicative senescence in CD8+ T cell following acute viral infection

Apoptosis, 2000
Viral infections are characterised by a large expansion of CD8+ effector T cells. Once generated, these T cells must be cleared and homeostasis re-established. In this review we describe two mechanisms, apoptosis and replicative senescence which are thought to play a vital role in this process.
F J, Plunkett, M V, Soares, M, Salmon, A N, Akbar   +3 more
openaire   +2 more sources

MicroRNAs in HIV infection: dual regulators of viral replication and host immunity

Naunyn-Schmiedeberg's Archives of Pharmacology
MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in regulating gene expression by binding to target messenger RNAs (mRNAs), leading to their degradation or translational repression. Over the past few years, significant progress has been made in understanding the role of miRNAs in various biological processes, including viral ...
Reda M. Mansour, Gharieb S. El-Sayyad, Nehal I. Rizk, Sherif S. Abdel Mageed, Mohamed Salah Basiouny, Salma A. El-Sayed, Salma Zaki Fayez, Moustafa Mahmoud Abdelaziz, Khaled Abuelhaded, Haidy Adel Fahmy, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Ahmed S. Doghish   +12 more
openaire   +2 more sources

Neuronal activity regulates viral replication of herpes simplex virus type 1 in the nervous system

Journal of Neurovirology, 2005
Herpes simplex virus types 1 and 2 (HSV-1, -2) infect and also establish latency in neurons. In the present study, the authors investigated the influence of neuronal activity on the replication of HSV-1. The results showed that the sodium channel blocker tetrodotoxin (TTX) and the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) could ...
Cheryl X, Zhang, Harrison, Ofiyai, Ming, He, Xuexian, Bu, Yanhua, Wen, William, Jia   +5 more
openaire   +2 more sources

The Role of Avian Retroviral Ltrs in the Regulation of Gene Expression and Viral Replication

1985
Publisher Summary This chapter discusses the structure and role of the long terminal repeats (LTRs) of the avian sarcoma-leukosis viruses (ASV-ALV). Many of the characteristics of the ASV-ALVs are typical of all retroviruses. Retroviruses comprise a diverse group of viruses which nevertheless share an unusual set of genetic and biological features ...
G, Ju, B R, Cullen
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[Advances in m 6A modification and its regulation of viral replication].

Yi chuan = Hereditas, 2019
N 6-methyladenosine (m 6A) is a prevalent modification of RNA in eukaryotes and plays an important role in the process of mRNA translocation, stabilization and translation. m 6A exerts different influences on the viral replication cycle, and both viral replication and host immune response to the virus are affected by m 6A.
Peng, Xue, Tao, Jiang, Xing Jia, Shen
openaire   +1 more source