Results 231 to 240 of about 186,764 (256)

Ebola virus replication is regulated by the phosphorylation of viral protein VP35

Biochemical and Biophysical Research Communications, 2020
Ebola virus (EBOV) is a zoonotic pathogen, the infection often results in severe, potentially fatal, systematic disease in human and nonhuman primates. VP35, an essential viral RNA-dependent RNA polymerase cofactor, is indispensable for Ebola viral replication and host innate immune escape.
Lin, Zhu, Ting, Gao, Weihong, Yang, Yaoning, Liu, Xuan, Liu, Yong, Hu, Yanwen, Jin, Ping, Li, Ke, Xu, Gang, Zou, Lei, Zhao, Ruiyuan, Cao, Wu, Zhong, Xianzhu, Xia, Cheng, Cao   +14 more
openaire   +2 more sources

A Human Cytomegalovirus-Encoded microRNA Regulates Expression of Multiple Viral Genes Involved in Replication

PLoS Pathogens, 2007
Although multiple studies have documented the expression of over 70 novel virus-encoded microRNAs (miRNAs), the targets and functions of most of these regulatory RNA species are unknown. In this study a comparative bioinformatics approach was employed to identify potential human cytomegalovirus (HCMV) mRNA targets of the virus-encoded miRNA miR-UL112-1.
Deborah Spector, Finn Grey, Jay A Nelson   +2 more
exaly   +7 more sources

Biomolecular Condensation of the Human Papillomavirus E2 Master Regulator with P53: Implications in Viral Replication

SSRN Electronic Journal, 2022
p53 exerts its tumour suppressor activity by modulating hundreds of genes and it can also repress viral replication. Such is the case of human papillomavirus (HPV) through targeting the E2 master regulator, but the biochemical mechanism is not known.
Borkosky, Silvia Susana, Fassolari, Marisol, Campos León, Karen, Rossi, Andrés Hugo, Salgueiro, Mariano, Pascuale, Carla Antonela, Martínez, Ramón Peralta, Gaston, Kevin, de Prat Gay, Gonzalo   +8 more
openaire   +3 more sources

MicroRNAs in HIV infection: dual regulators of viral replication and host immunity

Naunyn-Schmiedeberg's Archives of Pharmacology
MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in regulating gene expression by binding to target messenger RNAs (mRNAs), leading to their degradation or translational repression. Over the past few years, significant progress has been made in understanding the role of miRNAs in various biological processes, including viral ...
Reda M. Mansour, Gharieb S. El-Sayyad, Nehal I. Rizk, Sherif S. Abdel Mageed, Mohamed Salah Basiouny, Salma A. El-Sayed, Salma Zaki Fayez, Moustafa Mahmoud Abdelaziz, Khaled Abuelhaded, Haidy Adel Fahmy, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Ahmed S. Doghish   +12 more
openaire   +2 more sources

The Role of Avian Retroviral Ltrs in the Regulation of Gene Expression and Viral Replication

1985
Publisher Summary This chapter discusses the structure and role of the long terminal repeats (LTRs) of the avian sarcoma-leukosis viruses (ASV-ALV). Many of the characteristics of the ASV-ALVs are typical of all retroviruses. Retroviruses comprise a diverse group of viruses which nevertheless share an unusual set of genetic and biological features ...
G, Ju, B R, Cullen
openaire   +2 more sources

HTLV-1-encoded p30II is a post-transcriptional negative regulator of viral replication

Nature Medicine, 2004
Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) persists despite a vigorous virus-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% of infected individuals. Here we report that HTLV-1 has evolved a genetic function to restrict its own replication by a novel post-transcriptional mechanism.
Christophe, Nicot, Miroslav, Dundr, Julie M, Johnson, Jake R, Fullen, Norma, Alonzo, Risaku, Fukumoto, Gerald L, Princler, David, Derse, Tom, Misteli, Genoveffa, Franchini   +9 more
openaire   +2 more sources

Interplay between host cell and hepatitis C virus in regulating viral replication

bchm, 2009
Abstract Viral life cycle as that of the hepatitis C virus (HCV) completely relies on host cell infrastructure, presupposing that the virus has evolved mechanisms to utilize and control all cellular molecules or pathways required for viral life cycle.
Johannes G, Bode, Erwin D, Brenndörfer, Juliane, Karthe, Dieter, Häussinger   +3 more
openaire   +2 more sources

Interferon-regulated viral replication in chronically HIV1-infected promonocytic U937 cells

Research in Virology, 1991
To further document the role of interferons in the restriction of HIV1 replication in cells of the monocyte/macrophage lineage, the antiviral effects of alpha-interferon (IFN alpha) were studied in chronically HIV 1-infected promonocytic cells U937, in which IFN alpha was endogenously produced or to which recombinant IFN alpha was added.
K, Macé, L, Gazzolo
openaire   +2 more sources

Regulation of Viral Transcription and DNA Replication by the SV40 Large T Antigen

1981
Simian Virus 40 (SV40) provides a particularly useful model for studying gene regulation at the molecular level because it is one of the simplest and most thoroughly characterized (Tooze 1980) viral systems known to undergo a well-defined developmental cycle in mammalian cells.
openaire   +2 more sources

A dual-function movement protein regulates viral replication suppression and movement facilitation in plant viral infections

Plant Physiology
Abstract Viral replication and intracellular movement are essential and interdependent steps during plant viral infections. Mechanistic insights into each step have been established, but the regulatory interplay between these processes and their underlying molecular mechanisms remain poorly understood.
Shan Bu, Lujia Wang, Xiangwen Luo, Zina Lin, Yu Zhang, Shijun Li, Xiao Yang, Jian Wu, Yuwen Lu, Hongying Zheng, Guanwei Wu, Shaofei Rao, Fei Yan, Deyong Zhang, Jiejun Peng, Songbai Zhang, Yong Liu   +16 more
openaire   +2 more sources